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UID:DSC-11661
DTSTART;TZID=Europe/Berlin:20160830T110000
SEQUENCE:1472542596
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20160830T123000
URL:https://dresden-science-calendar.de/calendar/de/detail/11661
LOCATION:MPI-PKS\, Nöthnitzer Straße 3801187 Dresden
SUMMARY:Kuan: Nonlinear dynamics and phase space flows to understand the ph
 ase behavior of motor protein motion on antiparallel filaments
CLASS:PUBLIC
DESCRIPTION:Speaker: Hui-Shun Kuan\nInstitute of Speaker: University of Col
 orado\nTopics:\nPhysik\n Location:\n  Name: MPI-PKS (Room 1D1)\n  Street: 
 Nöthnitzer Straße 38\n  City: 01187 Dresden\n  Phone: + 49 (0)351 871 0\
 n  Fax: \nDescription: Motor protein motion on biopolymers can be describe
 d by driven diffusive models related to the totally asymmetric exclusion p
 rocess (TASEP). Inspired by recent experiments on the motion of kinesin-4 
 motors on antiparallel microtubule overlaps\, we develop a model incorpora
 ting the TASEP on two antiparallel lanes with binding kinetics and lane sw
 itching. We determine the steady-state motor density profiles and phase di
 agram using phase space flows at the mean-field level. We compared our res
 ults to kinetic Monte Carlo simulations. Phases previously identified for 
 the single-filament model occur in the limit of zero switching rate. In ad
 dition\, lane switching couples the density profiles on the two lanes and 
 can lead to a new phase not possible for a single filament: switching move
 s motors from the higher density lane to lower density lane\, causing loca
 l jamming and creating multiple domain walls. We determine the phase diagr
 am of the model and discuss the boundary layer length as a function of bul
 k motor concentration and motor speed.
DTSTAMP:20260430T121427Z
CREATED:20160810T074012Z
LAST-MODIFIED:20160830T073636Z
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