Cell shape and morphogenesis: sub-cellular and supra-cellular mechanisms

Datum

13.01.2017

Zeit

11:00 - 12:00

Sprecher

Maria Leptin

Zugehörigkeit

EMBO Director & Professor at the Institute of Genetics University of Cologne

Sprache

en

Hauptthema

Biologie

Andere Themen

Biologie, Medizin

Host

Stephan Grill

Beschreibung

Abstract:Maria Leptin has made contributions to several fields, ranging from innate and adaptive immunity to developmental genetics and cell biology. She is best known for her studies of what is considered the most profound embryonic process: gastrulation. Leptin discovered the essential players that regulate shape changes during gastrulation and elucidated their mechanism of action. Using genetics, biochemistry and cell biology, she established the full regulatory cascade from a critical transcription factor during gastrulation to its target effector genes. Her current interest is to understand the physical basis of the coordination of morphogenetic activities throughout the entire organismPublications:Leptin, M. and B. Grunewald. (1990).Cell shape changes during gastrulation in Drosophila.Development 110, 73-84.Leptin, M. (1991)twist and snail as positive and negative regulators during Drosophila mesoderm development.Genes and Development 5, 1568-1576Barrett, K., Leptin, M. and Settleman, J (1997)The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulationCell 91, 905-915Seher, T. and Leptin, M. (2000)Tribbles, a cell cycle brake that coordinates proliferation and morphogenesis during Drosophila gastrulationCurrent Biology 10, 623-629Kölsch V, Seher T, Fernandez-Ballester GJ, Serrano L, Leptin M. (2007)Control of Drosophila gastrulation by apical localization of adherens junctions and RhoGEF2.Science 315, 384-6.Stein C, Caccamo M, Laird G, Leptin M. (2007)Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish.Genome Biol. 8: R251.1 – 251.23Rembold M, Ciglar L, Yáñez-Cuna JO, Zinzen RP, Girardot C, Jain A, Welte MA, Stark A, Leptin M, Furlong EE. (2014)A conserved role for Snail as a potentiator of active transcription.Genes Dev. 28:167-81.Gilmour, D., Rembold, M., and Leptin, M. (2017)From Morphogen To Morphogenesis and BackNature (in press).

Links

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Letztmalig verändert: 13.01.2017, 08:54:00