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UID:DSC-12754
DTSTART;TZID=Europe/Berlin:20170516T190000
SEQUENCE:1494841681
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20170516T200000
URL:https://dresden-science-calendar.de/calendar/de/detail/12754
LOCATION:TUD Hörsaalzentrum\, Bergstraße 6401069 Dresden
SUMMARY:Modrich: Mechanisms in DNA mismatch repair
CLASS:PUBLIC
DESCRIPTION:Speaker: Paul Modrich\nInstitute of Speaker: 2015 Nobel Prize i
 n Chemistry\nTopics:\nChemie\n Location:\n  Name: TUD Hörsaalzentrum ()\n
   Street: Bergstraße 64\n  City: 01069 Dresden\n  Phone: +49 351 463-3445
 7\n  Fax: +49 351 463-32883\nDescription: Biochemist Paul Modrich was awar
 ded the 2015 Nobel Prize in Chemistry along with Tomas Lindahl and Aziz Sa
 ncar \"for mechanistic studies of DNA repair.\" Paul Modrich worked over d
 ecades on the idea of decoding the repair mechanism in the DNA code. Just 
 as with all cell mechanisms\, chromosome replication is not free from mist
 akes\, misspellings in the genetic code are constantly happening. In 1989\
 , Modrich succeeded in identifying the mismatch repair system (MMR) in cel
 ls. By studying bacterial viruses\, Paul Modrich showed how methyl groups 
 attached to the DNA molecule act as signals for repairing incorrect replic
 ations of DNA. Repair enzymes then cut out the mismatched base and replace
 s it. Mismatch repair is a mutation avoidance system\, if it does not work
  properly\, cancer and other diseases can develop. 
DTSTAMP:20260521T200114Z
CREATED:20170410T084712Z
LAST-MODIFIED:20170515T094801Z
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