How experience contributes to circuit remodeling in the adult hippocampus

Datum

12.05.2017

Zeit

11:00 - 12:00

Sprecher

Dr. Alejandro F. Schinder Buenos Aires, Laboratory of Neuronal Plasticity)

Zugehörigkeit

Leloir Institute (CONICET

Serie

CMCB Life Sciences Seminar

Sprache

en

Hauptthema

Biologie

Andere Themen

Biologie, Medizin

Host

Prof. Federico Calegari

Beschreibung

About the research of Dr. Schinder:The dentate gyrus of the hippocampus displays a unique degree of plasticity conveyed by its ability to generate and integrate new principal neurons (granule cells, GCs) through life. Adult-born GCs are important for specific forms of memory, such as those that demand fine discrimination of subtle differences, particularly during spatial tasks. My laboratory has focused on understanding the modifications of local dentate networks produced by the incorporation of newly generated GCs, their interaction with the microenvironment (niche), and their functional implications. Our recent findings reveal that new GCs may play distinct roles in memory encoding as they walk through the road of development. In my talk I will discuss recent approaches combining opto- and chemogenetics that we have used to understand the function of developing GCs and the mechanisms that transduce behavioral experiences into changes in their integration and plasticity.5 most important publications:Alvarez DD, Giacomini D, Yang SM, Trinchero MF, Temprana SG, Büttner KA, Beltramone N, Schinder AF. A Disynaptic Feedback Network Activated by Experience Promotes the Integration of New Granule Cells. Science 354:459-465, 2016.Temprana SG, Mongiat LA, Yang SM, Trinchero MF, Alvarez DD, Kropf E, Giacomini DP, Beltramone N, Lanuza GM, Schinder AF. Delayed coupling to feedback inhibition during a critical period for the integration of adult-born granule cells. Neuron 85: 116–130, 2015.Marín-Burgin A, Mongiat LA, Pardi MB and Schinder AF. Unique Processing During a Period of High Excitation/Inhibition Balance in Adult-Born Neurons. Science 335: 1238-42, 2012.Piatti VC, Davies Sala MG, Espósito MS, Mongiat LA, Trinchero MF and Schinder AF. The Timing for Neuronal Maturation in the Adult Hippocampus is Modulated by Local Network Activity. The Journal of Neuroscience 31: 7715-7728, 2011. Espósito MS, Piatti VC, Laplagne DA, Morgenstern NA, Ferrari C, Pitossi FJ, and Schinder AF. Neuronal Differentiation in the Adult Hippocampus Recapitulates Embryonic Development. The Journal of Neuroscience 25: 10074-10086, 2005.

Links

• to announcement of the organizer

Letztmalig verändert: 12.05.2017, 09:56:47