Pattern Formation in Active Cytoskeletal Systems

Datum

19.05.2017

Zeit

11:00 - 12:00

Sprecher

Andreas Bausch

Zugehörigkeit

Biophysics, TU Munich

Sprache

en

Hauptthema

Biologie

Andere Themen

Biologie, Medizin

Host

Prof. Stephan Grill

Beschreibung

Abstract:Living cells rely on the self-organization mechanisms of cytoskeleton to adapt to their requirements. In processes such as cell division, or cellular motility rely on the controlled self-assembly and disassembly of well defined active cytoskeletal structures interacting with lipid membranes. One important and promising strategy to identify the underlying governing principles is to quantify the underlying physical processes in model systems mimicking functional units of living cell. Here I’ll present in vitro minimal model systems consisting of active microtubule and actin filament systems which show pattern formation resulting from active transport processes. I will discuss how a balance of local force exertion and tension generation results in shape transformations, blebbing, invagination or tethering of lipid membranes. Publications:L. Rossetti, L. Kuntz, E. Kunold, J. Schock, K. Müller, H. Grabmayr, J. Stolberg-Stolberg, F. Pfeiffer, S. Sieber, R. Burgkart, A.R. Bausch (2017) The microstructure and micromechanics of the tendon–bone insertionNature Materials, DOI: 10.1038/NMAT4863 1. E. Loiseau, J. A. M. Schneider, F. C. Keber, C. Pelzl, G. Massiera, G. Salbreux, A. R. Bausch (2016). Shape remodeling and blebbing of active cytoskeletal vesicles, Science Advances; 2: e1500465.R. Suzuki, C. A. Weber, E. Frey and A. R. Bausch (2015). Polar pattern formation in driven filament systems requires non-binary particle collisions. Nature Physics, 11, 839–843.F. C. Keber, E. Loiseau, T. Sanchez, S. J. DeCamp, L. Giomi, M. J. Bowick, M. C. Marchetti, Z. Dogic and A. R. Bausch (2014). Topology and Dynamics of Active Nematic Vesicles, Science, 345, 6201.S. Köhler, K. M. Schmoller, A. H. Crevenna and A. R. Bausch (2012). Regulating Contractility of the Actomyosin Cytoskeleton by pH, Cell Reports 2, 433–439

Links

• to announcement of the organizer

Letztmalig verändert: 19.05.2017, 09:43:31