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UID:DSC-13300
DTSTART;TZID=Europe/Berlin:20170822T133000
SEQUENCE:1503388822
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20170822T143000
URL:https://dresden-science-calendar.de/calendar/de/detail/13300
LOCATION:IFW\, Helmholtzstraße 2001069 Dresden
SUMMARY:Schwarz: Non-invasive manipulation of gametes by micromotors for as
 sisted reproduction
CLASS:PUBLIC
DESCRIPTION:Speaker: Lukas Schwarz\nInstitute of Speaker: IIN\nTopics:\nMat
 erialien\, Physik\n Location:\n  Name: IFW (B3E.26\, Leibniz-IFW Dresden)\
 n  Street: Helmholtzstraße 20\n  City: 01069 Dresden\n  Phone: \n  Fax: \
 nDescription: Infertility is defined by the World Health Organization (WHO
 ) as a disease of the reproductive system [1]. If conventional therapeutic
  or surgical methods fail to treat such male or female factor disorders\, 
 assisted reproductive technology (ART)\, which comprises the in vitro hand
 ling of gametes (sperm cells and oocytes) or zygotes/embryos\, serves as l
 ast resort to make pregnancy possible [1]. Besides ethical concerns\, the 
 major drawbacks of ART are success rate\, medical risks and patient discom
 fort of its last step\, the re-implantation of in vitro-cultured embryos [
 2]. To solve these difficulties\, we investigate non-invasive surgery oper
 ations by un-tethered\, microrobotic devices to directly manipulate gamete
 s and zygotes (fertilized oocytes) with the aim to assist fertilization an
 d embryo development in vivo.  Manipulation and assistance of cells by art
 ificial attachments or carrier devices to realize biomedical applications 
 experienced significant attention and progress in recent years [3]. In our
  labs\, we showed the transportation of individual immotile sperm cells to
  the oocyte by magnetic microhelices in an in vitro setup to overcome seve
 re male factor infertility [4]. Building up on this work\, methods of coll
 ective sperm transport and delivery were explored to improve efficiency. A
 lso\, the manipulation of oocytes and zygotes by scaled-up magnetic microm
 otors to assist embryo development was investigated.  Finally\, a novel 3D
  cell culture system to cultivate oviduct epithelial cells in tubular conf
 inement was designed to investigate sperm and oocyte behavior and micromot
 or-assisted reproduction technologies under realistic physiological condit
 ions in an artificial oviduct setup. Current results and future experiment
 s will be discussed in this seminar talk.
DTSTAMP:20260626T185248Z
CREATED:20170815T075649Z
LAST-MODIFIED:20170822T080022Z
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