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UID:DSC-13703
DTSTART;TZID=Europe/Berlin:20171103T160000
SEQUENCE:1509695229
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20171103T170000
URL:https://dresden-science-calendar.de/calendar/de/detail/13703
LOCATION:TUD CRTD\, Fetscherstraße 10501307 Dresden
SUMMARY:Ninov: Aging is a heterogeneous process across individual cells
CLASS:PUBLIC
DESCRIPTION:Speaker: Nikolay Ninov\, Sharan Janjuha\nInstitute of Speaker: 
 Predoc\nTopics:\nBiologie\, Medizin\n Location:\n  Name: TUD CRTD (CRTD\, 
 auditorium left)\n  Street: Fetscherstraße 105\n  City: 01307 Dresden\n  
 Phone: +49 (0)351 458 82052\n  Fax: +49 (0)351 458 82059 \nDescription: In
 dividual organisms age at different rates\, however\, it remains unclear h
 ow aging alters the properties of individual cells\, including their capac
 ity for renewal. Using single-cell approaches\, here we show that zebrafis
 h pancreatic beta-cells exhibit a heterogeneous upregulation of transcript
 s involved in endoplasmic reticulum stress\, inhibition of growth factor s
 ignaling and inflammation\, including NF-kB signaling with age. We link th
 e heterogeneity in NF-kB signaling activation in beta-cells to differences
  in their proliferation and gene-expression. In younger islets\, beta-cell
 s with higher NF-kB-activity proliferate less compared to their neighbors 
 with lower activity\, and upregulate prematurely socs2\, a gene naturally 
 expressed in aged beta-cells. In turn\, socs2 can inhibit beta-cell prolif
 eration in a cell-autonomous manner. NF-kB activation correlates with the 
 recruitment of tnfα-expressing immune cells\, pointing towards a role for
  the islet microenvironment in this activity. We propose that the renewal 
 potential of beta-cells declines in a heterogeneous manner with age and id
 entify NF-kB signaling as a marker of this heterogeneity. The identificati
 on of reliable markers of beta-cell aging will be key to enable early inte
 rventions for diabetes prevention\, as well as for promoting beta-cell rep
 air and renewal.
DTSTAMP:20260711T193528Z
CREATED:20171102T074829Z
LAST-MODIFIED:20171103T074709Z
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