BEGIN:VCALENDAR
VERSION:2.0
PRODID:www.dresden-science-calendar.de
METHOD:PUBLISH
CALSCALE:GREGORIAN
X-MICROSOFT-CALSCALE:GREGORIAN
X-WR-TIMEZONE:Europe/Berlin
BEGIN:VTIMEZONE
TZID:Europe/Berlin
X-LIC-LOCATION:Europe/Berlin
BEGIN:DAYLIGHT
TZNAME:CEST
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
DTSTART:19810329T030000
RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=3;BYDAY=-1SU
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:CET
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
DTSTART:19961027T030000
RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=10;BYDAY=-1SU
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
UID:DSC-13760
DTSTART;TZID=Europe/Berlin:20171120T150000
SEQUENCE:1511251420
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20171120T160000
URL:https://dresden-science-calendar.de/calendar/de/detail/13760
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Janke: Controlling microtubule functions with the tubulin code
CLASS:PUBLIC
DESCRIPTION:Speaker: Carsten Janke\nInstitute of Speaker: Dept. Genotoxic S
 tress and Cancer\, Institut Curie\, Orsay\, France\nTopics:\nBiologie\n Lo
 cation:\n  Name: MPI-CBG (MPI-CBG Galleria)\n  Street: Pfotenhauerstraße 
 108\n  City: 01307 Dresden\n  Phone: +49 351 210-0\n  Fax: +49 351 210-200
 0\nDescription: The tubulin code is a signalling mechanism that\, by alter
 ing the identity of single tubulin units of microtubules\, controls and fi
 ne-tunes microtubule functions in cells. The code is generated by the expr
 ession of alternative tubulin genes\, called ‘isotypes’\, and by the g
 eneration of a range of complex posttranslational modifications. Polygluta
 mylation\, polyglycylation and detyrosination are modifications localized 
 at the outer surface of microtubules\, and are therefore likely to regulat
 e the interactions with microtubule-associated proteins. Enzymes that cata
 lyse those modifications are members of an evolutionary conserved family o
 f tubulin tyrosine ligase like proteins (TTLL)\, whereas reverse enzymes (
 until present only deglutamylases have been identified) are members of the
  cytosolic carboxy peptidase family (CCP). I will present our current work
  in mouse models for polyglutamylation and glycylation. We demonstrate an 
 important role of polyglutamylation in neurodegeneration\, which is most l
 ikely mediated by alterations of neuronal transport. Glycylation plays a k
 ey role in stabilizing cilia and flagella\, and is also important for prim
 ary cilia. Moreover\, both polyglutamylation and polyglycylation play a ke
 y role in male fertility. Our current results show that the tubulin code i
 s a fine-tuning mechanism of microtubule functions with key roles in a ran
 ge of physiological functions.
DTSTAMP:20260629T170308Z
CREATED:20171114T073920Z
LAST-MODIFIED:20171121T080340Z
END:VEVENT
END:VCALENDAR