Cell Surface as an Active Composite - local control of forces and composition with functional implications

Datum

16.01.2018

Zeit

11:00 - 12:00

Sprecher

Madan Rao

Zugehörigkeit

NCBS, Tata Institute for Fundamental Research, Bangalore, India

Sprache

en

Hauptthema

Biologie

Andere Themen

Biologie

Host

Marino Zerial

Beschreibung

Over the years we and others have shown that the physical organization and dynamics of many signaling molecules at the cell surface are locally controlled by their coupling to the thin cortical actomyosin layer, which actively drives local cell membrane composition and shape. In many cases, this organisation involves a collaboration with specific lipids on the cell surface. While this active organisation occurs constitutively, it gets locally amplified by external cues. I will discuss our current understanding in terms of both theory and experiments. Towards the end, I hope to be able to discuss possible functional implications of such a local active control.

Letztmalig verändert: 17.01.2018, 08:35:31