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UID:DSC-14145
DTSTART;TZID=Europe/Berlin:20190124T110000
SEQUENCE:1548374995
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20190124T120000
URL:https://dresden-science-calendar.de/calendar/de/detail/14145
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Duboule: Long-range Gene Regulation During Vertebrate Development a
 nd Evolution
CLASS:PUBLIC
DESCRIPTION:Speaker: Denis Duboule\nInstitute of Speaker: School of Life Sc
 iences\, Ecole Polytechnique Fédérale\, Lausanne\, Department of Genetic
 s and Evolution\, University of Geneva\, Switzerland and Collège de Franc
 e\, Paris \nTopics:\nBiologie\n Location:\n  Name: MPI-CBG (MPI-CBG Audito
 rium (big half))\n  Street: Pfotenhauerstraße 108\n  City: 01307 Dresden\
 n  Phone: +49 351 210-0\n  Fax: +49 351 210-2000\nDescription: During vert
 ebrate development\, clustered Hox genes are controlled by enhancers actin
 g over very long distances and localized within two distinct Topologically
  Associating Domains (TADs) flanking the genomic cluster. In this talk I w
 ill first introduce the experimental system and then discuss two related i
 ssues concerned with this complex bimodal regulatory strategy. The first q
 uestion has to do with the mechanism underlying the boundary effect\, whic
 h prevents the TADs to interact either with one another\, or with target g
 enes located on either side of this boundary. The second point is concerne
 d with the biological relevance of this boundary\, i.e. its relevance duri
 ng development and its function in protecting anterior structures from the
  dominant effect of posterior genes.
DTSTAMP:20260701T081238Z
CREATED:20180216T080331Z
LAST-MODIFIED:20190125T000955Z
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