Tension and TOROIDs – regulation of TOR activity by phase separation
- Datum
- 07.02.2019
- Zeit
- 11:00 - 12:00
- Sprecher
- Robbie Loewith
- Zugehörigkeit
- University of Geneva, Switzerland
- Serie
- MPI-CBG Thursday Seminar
- Sprache
- en
- Hauptthema
- Biologie
- Andere Themen
- Biologie
- Host
- Suzanne Eaton
- Beschreibung
- The Target Of Rapamycin (TOR) is a ser/thr protein kinase conserved across eukaryote evolution. TOR assembles into two, distinct complexes (TORC1 and TORC2) that serve to maintain cellular homeostasis. TORC1 is best appreciated for its role in cell mass/volume control while TORC2 appears to control the surface area of the plasma membrane. I will present our recent investigations that revealed how the kinase activity of TORC1 is regulated at the molecular level (through polymerization into a huge helix we call a TOROID) and how membrane tension is sensed upstream of TORC2 (through phase separation of PIP2).
Letztmalig verändert: 08.02.2019, 01:09:33
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Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG Auditorium (big half))Pfotenhauerstraße10801307Dresden
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- +49 351 210-0
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- +49 351 210-2000
- MPI-CBG
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- http://www.mpi-cbg.de
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Max Planck Institute of Molecular Cell Biology and GeneticsPfotenhauerstraße10801307Dresden
- Telefon
- +49 351 210-0
- Fax
- +49 351 210-2000
- MPI-CBG
- Homepage
- http://www.mpi-cbg.de
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