Precise genome engineering to empower drug discovery

Datum

18.01.2019

Zeit

15:00 - 16:00

Sprecher

Marcello Maresca

Zugehörigkeit

AstraZeneca Research Gothenburg, Sweden

Sprache

en

Hauptthema

Biologie

Andere Themen

Biologie, Medizin

Host

Prof. Dr. Francis Stewart

Beschreibung

InformationGene and base editing hold great promises in the prevention and treatment of genetic diseases. Predicting the on-target and off-target activities of Cas9/CRISPR and Base Editors is an essential requirement for a safe and efficacious treatment. Recent progress shows how the analysis and modulation of DNA repair pathway can be applied to predict base and genome editing outcomes. Taheri-Ghahfarokhi, Amir, et al. Decoding non-random mutational signatures at Cas9 targeted sites. Nucleic acids research 46.16 (2018): 8417-8434.Akcakaya, Pinar, et al. In vivo CRISPR editing with no detectable genome-wide off-target mutations. Nature 561.7723 (2018): 416.Wienert, Beeke, et al. Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq. bioRxiv (2018): 469635.

Links

• to announcement of the organizer

Letztmalig verändert: 18.01.2019, 01:09:40