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UID:DSC-1633
DTSTART;TZID=Europe/Berlin:20111007T110000
SEQUENCE:1317222042
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20111007T120000
URL:https://dresden-science-calendar.de/calendar/de/detail/1633
LOCATION:BioZ\, Tatzberg 47-4901307 Dresden
SUMMARY:Trede: 450 Million Years of T cell Leukemia: Models and Drug Screen
 s in Zebrafish
CLASS:PUBLIC
DESCRIPTION:Speaker: Nikolaus S. Trede\nInstitute of Speaker: The Huntsman 
 Cancer Institute\, University of Utah \nTopics:\nMedizin\n Location:\n  Na
 me: BioZ (5th floor\, conference rooms 1&2)\n  Street: Tatzberg 47-49\n  C
 ity: 01307 Dresden\n  Phone: \n  Fax: \nDescription: The lab of Nikolaus T
 rede is focused on pathologic T lymphocyte development using the zebrafish
  model. The two main areas of study are models of T cell immunodeficiency 
 and T acute lymphoblastic leukemia (T-ALL). The Trede lab has generated a 
 number of mutant zebrafish lines that have defects in T cell and/or thymus
  development\, and has mapped and positionally cloned several of these. Th
 ey have also identified three mutant lines with heritable predisposition t
 o T-ALL. These models were used to determine high-risk T-ALL signatures ba
 sed on gene expression\, copy number aberrations and epigenetic changes. E
 xploiting the versatility of our T cell reporting transgenic zebrafish lin
 e\, we have also conducted a small molecule screen designed to identify ne
 w drugs with anti-T-ALL activity. This screenresulted in the identificatio
 n of Lenaldekar with selective activities against hematologic malignancies
 .
DTSTAMP:20260618T003003Z
CREATED:20110915T132718Z
LAST-MODIFIED:20110928T150042Z
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