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UID:DSC-18190
DTSTART;TZID=Europe/Berlin:20210929T110000
SEQUENCE:1632175606
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20210929T120000
URL:https://dresden-science-calendar.de/calendar/de/detail/18190
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:So: A new phase in egg biology
CLASS:PUBLIC
DESCRIPTION:Speaker: Chun So\nInstitute of Speaker: Max Planck Institute fo
 r Biophysical Chemistry\, Göttingen\nTopics:\n\n Location:\n  Name: MPI-C
 BG (MPI-CBG Auditorium)\n  Street: Pfotenhauerstraße 108\n  City: 01307 D
 resden\n  Phone: +49 351 210-0\n  Fax: +49 351 210-2000\nDescription: Aneu
 ploidy in human eggs is a leading cause of miscarriages and genetic disord
 ers such as Down syndrome. Unlike somatic cells\, mammalian eggs segregate
  chromosomes without centrosomes. How mammalian eggs assemble acentrosomal
  spindles and why spindle assembly in human eggs is error-prone remain poo
 rly understood.  In this talk\, I will present our work on the discovery o
 f the liquid-like meiotic spindle domain (LISD)\, a conserved subcellular 
 structure that forms by phase separation in mammalian eggs. The LISD selec
 tively concentrates multiple microtubule regulatory factors and allows the
 m to diffuse rapidly within the spindle volume. Disruption of the LISD dis
 perses these factors throughout the cytoplasm and leads to severe spindle 
 assembly defects. Our data suggest a model whereby the LISD promotes acent
 rosomal spindle assembly by serving as a reservoir that sequesters and mob
 ilizes microtubule regulatory factors in proximity to spindle microtubules
 .   I will also present our recent findings on the cause of spindle instab
 ility in human eggs\, and discuss potential strategies to restore the fide
 lity of chromosome segregation in human eggs.
DTSTAMP:20260625T082018Z
CREATED:20210916T220537Z
LAST-MODIFIED:20210920T220646Z
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