CMCB Extraordinary Seminar: Prof. Cristina Cebrián, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Developmental Biology, Department of Pediatrics

Datum

07.03.2023

Zeit

11:00 - 12:00

Sprache

en

Hauptthema

Willkommen

Andere Themen

Willkommen

Beschreibung

Host: Federico Calegari (CRTD)

Title: "The twists and turns of nephrogenesis, segment differentiation and cystic disease"

Abstract:

The mammalian kidney is wonderfully complex, both functionally and anatomically. We employ mouse models, iPSC-derived kidney organoids, molecular and cellular biology to study how this anatomical complexity arises during embryonic development, and how certain genetic diseases compromise kidney structure and function. 

5 most important publications:

1. Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney. (https://pubmed.ncbi.nlm.nih.gov/30166318/)Menon R, Otto EA, Kokoruda A, Zhou J, Zhang Z, Yoon E, Chen YC, Troyanskaya O, Spence JR, Kretzler M, Cebrián C. Development. 2018 Aug 30;145(16):dev164038. doi: 10.1242/dev.164038. PMID: 30166318 Free PMC article.

2. Ret and Etv4 Promote Directed Movements of Progenitor Cells during Renal Branching Morphogenesis. (https://pubmed.ncbi.nlm.nih.gov/26894589/)Riccio P, Cebrian C, Zong H, Hippenmeyer S, Costantini F. PLoS Biol. 2016 Feb 19;14(2):e1002382. doi: 10.1371/journal.pbio.1002382. eCollection 2016 Feb. PMID: 26894589 Free PMC article.

3. The number of fetal nephron progenitor cells limits ureteric branching and adult nephron endowment. (https://pubmed.ncbi.nlm.nih.gov/24656820/)Cebrian C, Asai N, D'Agati V, Costantini F. Cell Rep. 2014 Apr 10;7(1):127-37. doi: 10.1016/j.celrep.2014.02.033. Epub 2014 Mar 20. PMID: 24656820 Free PMC article.

4. Kidney development in the absence of Gdnf and Spry1 requires Fgf10. (https://pubmed.ncbi.nlm.nih.gov/20084103/)Michos O, Cebrian C, Hyink D, Grieshammer U, Williams L, D'Agati V, Licht JD, Martin GR, Costantini F. PLoS Genet. 2010 Jan 15;6(1):e1000809. doi: 10.1371/journal.pgen.1000809. PMID: 20084103 Free PMC article.

5. Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis. (https://pubmed.ncbi.nlm.nih.gov/19898483/)Lu BC, Cebrian C, Chi X, Kuure S, Kuo R, Bates CM, Arber S, Hassell J, MacNeil L, Hoshi M, Jain S, Asai N, Takahashi M, Schmidt-Ott KM, Barasch J, D'Agati V, Costantini F. Nat Genet. 2009 Dec;41(12):1295-302. doi: 10.1038/ng.476. Epub 2009 Nov 8. PMID: 19898483 Free PMC article.

Everybody is very welcome.

Links

• Termindetails auf den Webseiten der TU Dresden (https://tu-dresden.de)

Letztmalig verändert: 07.03.2023, 07:38:52