Mechanics and stress in cellular development, adaptation and aging

Datum

15.05.2023

Zeit

11:00 - 12:00

Sprecher

Rong Li

Zugehörigkeit

Mechanobiology Institute, National University of Singapore & Department of Cell Biology, Johns Hopkins University School of Medicine

Sprache

en

Hauptthema

Biologie

Host

Extraordinary Thursday seminar - Stephan Grill

Beschreibung

Mechanical processes are central to diverse cellular functions but can also be sources of cellular stress leading to aging phenotypes. My lab currently investigates three problems related to cell mechanics and stress: 1) how intracellular fluid dynamics coupled with cytoskeletal forces drive early mammalian development and reproductive aging; 2) how stress-induced protein aggregation and subsequent disaggregation are orchestrated by and affect organelles such as mitochondria and ER; and 3) how genome stability is affected by physical stress and how this contribute to cellular adaptation and cancer evolution. I will present a combination of recent findings in the first two areas of our research.

Letztmalig verändert: 16.05.2023, 07:37:48