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BEGIN:VEVENT
UID:DSC-20369
DTSTART;TZID=Europe/Berlin:20231212T110000
SEQUENCE:1702449458
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20231212T120000
URL:https://dresden-science-calendar.de/calendar/de/detail/20369
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:G: The Faraday Scalpel: on-demand manipulation of oxygen and reacti
 ve oxygen species in biological environment
CLASS:PUBLIC
DESCRIPTION:Speaker: Eric Daniel G&amp\;#322\;owacki\nInstitute of Speaker:
  Bioelectronics Materials and Devices Laboratory\, Central European Instit
 ute of Technology\, Brno University of Technology\, Czech Republic\nTopics
 :\n\n Location:\n  Name: MPI-CBG (MPI-CBG Galleria)\n  Street: Pfotenhauer
 straße 108\n  City: 01307 Dresden\n  Phone: +49 351 210-0\n  Fax: +49 351
  210-2000\nDescription: Oxygen is the fundamental electron acceptor in met
 abolism. As a byproduct of aerobic respiration\, various reactive oxygen s
 pecies (ROS) are formed. The balance of oxygenation and ROS is a critical 
 aspect of homeostasis. We present the concept of using electrochemical met
 hods to manipulate the levels of oxygen and ROS in biological systems in o
 rder to produce a desired outcome. Extensive oxygen depletion combined wit
 h generation of large concentrations of ROS can lead to cell death\, which
  we propose is a novel and useful approach to precise electrosurgery of pa
 thogenic tissues. Lower levels of oxygen reduction/ROS generation can alte
 r the function of numerous biological pathways. Of particular interest is 
 targeting ion channels using locally-generated hydrogen peroxide. This off
 ers a completely new method to alter electrophysiology in vitro or in vivo
 . I will present several examples of faradaic electrochemistry on oxygen a
 cting at the level of different targets. Electrochemical approaches can be
  used to precisely deoxygenate a given environment\, or combine deoxygenat
 ion with generation of ROS. A further level of electrochemical control is 
 using electrolysis to interrupt electrophysiological activity via rapid lo
 cal changes in pH. Examples of nerve lesioning in animal models will be sh
 own.
DTSTAMP:20260505T054739Z
CREATED:20231128T064005Z
LAST-MODIFIED:20231213T063738Z
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