Wl

CMCB Life Sciences Seminar: Dr. Kapil Bharti, National Eye Institute Bethesda, USA

Datum
08.08.2024
Zeit
13:00 - 14:00
Serie
CMCB Life Sciences Seminar
Sprache
en
Hauptthema
Willkommen
Andere Themen
Willkommen
Beschreibung

Host: Marius Ader (CRTD)

Title: “Translating RPE Biology into Disease Treatments Using Stem Cells.”

Abstract: I have more than 15 years of experience in eye development and differentiation of retinal pigment epithelium (RPE). Recently, my lab has capitalized on induced pluripotent stem (iPS) cell technology to develop therapies for degenerative eye diseases. Based on my past experience with RPE development, we optimized a robust protocol to differentiate RPE from human iPS cells. This protocol is highly efficient and reproducible in generating functional RPE cells. Combining this developmental biology approach with tissue engineering, we have grown iPSC-RPE monolayers on a biodegradable scaffold and developed methods to functionally authenticate these monolayers. The resulting iPSC-RPE tissue resembles native tissue in its physiological properties. This work has formed the basis for a phase 1/IIa clinical trial testing the RPE-scaffold as a therapeutic implant in advanced macular degeneration. In parallel, my lab also developed methods and assays to perform large-scale drug screen using iPSC-RPE grown in 384-well plates. These high throughput screens are being used to develop potential therapies for degenerative eye diseases. With our extensive experience in iPSC-RPE, we have derived dozens of iPS lines, which we have extensively characterized and genotyped.

Links

Letztmalig verändert: 08.08.2024, 07:35:46

Veranstaltungsort

Center for Regenerative Therapies DresdenFetscherstraße10501307Dresden
Telefon
+49 (0)351 458 82052
Fax
+49 (0)351 458 82059
E-Mail
TUD CRTD
Homepage
https://tu-dresden.de/cmcb/crtd

Veranstalter

Center for Molecular and Cellular Bioengineering (CMCB)01062Dresden
Telefon
+49 351 463-40359
Fax
+49 351 463-40322
E-Mail
TUD CMCB
Homepage
https://tu-dresden.de/cmcb
Scannen Sie diesen Code mit Ihrem Smartphone and bekommen Sie die Veranstaltung direkt in Ihren Kalender. Sollten Sie Probleme beim Scannen haben, vergrößern Sie den Code durch Klicken darauf.
  • AuAusgründung/Transfer
  • BaBauing., Architektur
  • BiBiologie
  • ChChemie
  • ElElektro- u. Informationstechnik
  • Sfür Schüler:innen
  • GsGesellschaft, Philos., Erzieh.
  • InInformatik
  • JuJura
  • MwMaschinenwesen
  • MtMaterialien
  • MaMathematik
  • MeMedizin
  • PhPhysik
  • PsPsychologie
  • KuSprache, Literatur und Kultur
  • UmUmwelt
  • VeVerkehr
  • WeWeiterbildung
  • WlWillkommen
  • WiWirtschaft