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Multi-module recording of neuronal activity and structures using graphene microelectrode arrays in the study of Niemann -Pick disease

Datum
05.12.2024
Zeit
13:00 - 15:00
Sprecher
Meng Lu
Zugehörigkeit
Institute of Advanced Clinical Medicine, Peking University
Serie
TUD nanoSeminar
Sprache
en
Hauptthema
Physik
Andere Themen
Physik
Host
Arezoo Dianat
Beschreibung
Simultaneously recording network activity and ultrastructural changes of the synapse can significantly advance our understanding of the structural basis of neuronal functions. The intricate changes in neuronal activity at millisecond-scale and the minute structural modifications at the synapse that are smaller than the diffraction limit present considerable hurdles for this undertaking. Here, we introduce a multi-module recording system based on graphene microelectrode arrays (G-MEAs), which facilitate high-resolution imaging at different scales and permit electrophysiological recordings with high temporal precision. In conjunction with G-MEAs, we also apply a straightforward machine learning algorithm to streamline the analysis of extensive data gathered from microelectrode array recordings. We illustrate that the integration of G-MEAs, machine learning-based spike analysis, and four-dimensional structured illumination microscopy (4D-SIM) provides a powerful tool for observing the effects of disease progression on hippocampal neurons. Furthermore, treating neurons with an inhibitor of intracellular cholesterol transport to mimic Niemann-Pick disease type C (NPC) results in a significant enlargement of synaptic boutons compared to untreated neurons, ultimately impairing neuronal signaling capabilities.
Links

Letztmalig verändert: 05.12.2024, 07:36:16

Veranstaltungsort

TUD Materials Science - HALHallwachsstraße301069Dresden
Homepage
https://navigator.tu-dresden.de/etplan/hal/00

Veranstalter

TUD Institute for Materials ScienceHallwachsstr.301069Dresden
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