Multi-module recording of neuronal activity and structures using graphene microelectrode arrays in the study of Niemann -Pick disease
- Datum
- 05.12.2024
- Zeit
- 13:00 - 15:00
- Sprecher
- Meng Lu
- Zugehörigkeit
- Institute of Advanced Clinical Medicine, Peking University
- Serie
- TUD nanoSeminar
- Sprache
- en
- Hauptthema
- Physik
- Andere Themen
- Physik
- Host
- Arezoo Dianat
- Beschreibung
- Simultaneously recording network activity and ultrastructural changes of the synapse can significantly advance our understanding of the structural basis of neuronal functions. The intricate changes in neuronal activity at millisecond-scale and the minute structural modifications at the synapse that are smaller than the diffraction limit present considerable hurdles for this undertaking. Here, we introduce a multi-module recording system based on graphene microelectrode arrays (G-MEAs), which facilitate high-resolution imaging at different scales and permit electrophysiological recordings with high temporal precision. In conjunction with G-MEAs, we also apply a straightforward machine learning algorithm to streamline the analysis of extensive data gathered from microelectrode array recordings. We illustrate that the integration of G-MEAs, machine learning-based spike analysis, and four-dimensional structured illumination microscopy (4D-SIM) provides a powerful tool for observing the effects of disease progression on hippocampal neurons. Furthermore, treating neurons with an inhibitor of intracellular cholesterol transport to mimic Niemann-Pick disease type C (NPC) results in a significant enlargement of synaptic boutons compared to untreated neurons, ultimately impairing neuronal signaling capabilities.
- Links
Letztmalig verändert: 05.12.2024, 07:36:16
Veranstaltungsort
TUD Materials Science - HALHallwachsstraße301069Dresden
- Homepage
- https://navigator.tu-dresden.de/etplan/hal/00
Veranstalter
TUD Institute for Materials ScienceHallwachsstr.301069Dresden
Legende
- Ausgründung/Transfer
- Bauing., Architektur
- Biologie
- Chemie
- Elektro- u. Informationstechnik
- für Schüler:innen
- Gesellschaft, Philos., Erzieh.
- Informatik
- Jura
- Maschinenwesen
- Materialien
- Mathematik
- Medizin
- Physik
- Psychologie
- Sprache, Literatur und Kultur
- Umwelt
- Verkehr
- Weiterbildung
- Willkommen
- Wirtschaft