PUFFFIN - Illuminating Cellular Neighbourhoods in Model Systems of Development
- Datum
- 04.02.2025
- Zeit
- 11:00 - 12:00
- Sprecher
- Tamina Lebek
- Zugehörigkeit
- Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, UK
- Sprache
- en
- Hauptthema
- Biologie
- Host
- Meritxell Huch
- Beschreibung
- Understanding how cells influence their neighbours is crucial for deciphering processes like development, homeostasis, and disease. Recent advances have introduced fluorescent protein-based methods to identify cellular neighbourhoods. I will present Positive Ultra-bright Fluorescent Fusion For Identifying Neighbours (PUFFFIN), a new neighbour-labelling system based on the secretion and uptake of a super-positive fluorescent protein. PUFFFIN enables precise and rapid identification, isolation, and profiling of neighbouring cells, even capturing transient interactions. Its modular design allows colour-of-choice labelling and transgene integration, making it highly versatile. I will also demonstrate how we are using PUFFFIN to study coordination of differentiation in mouse embryonic stem cells. This powerful tool offers a simple, sensitive, and customisable approach for profiling cell-cell communication in diverse contexts, paving the way for new insights into cellular interactions.
Letztmalig verändert: 04.02.2025, 07:37:47
Veranstaltungsort
Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG CBG Galleria II (VC))Pfotenhauerstraße10801307Dresden
- Telefon
- +49 351 210-0
- Fax
- +49 351 210-2000
- MPI-CBG
- Homepage
- http://www.mpi-cbg.de
Veranstalter
Max Planck Institute of Molecular Cell Biology and GeneticsPfotenhauerstraße10801307Dresden
- Telefon
- +49 351 210-0
- Fax
- +49 351 210-2000
- MPI-CBG
- Homepage
- http://www.mpi-cbg.de
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