Bi

PUFFFIN - Illuminating Cellular Neighbourhoods in Model Systems of Development

Datum
04.02.2025
Zeit
11:00 - 12:00
Sprecher
Tamina Lebek
Zugehörigkeit
Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, UK
Sprache
en
Hauptthema
Biologie
Host
Meritxell Huch
Beschreibung
Understanding how cells influence their neighbours is crucial for deciphering processes like development, homeostasis, and disease. Recent advances have introduced fluorescent protein-based methods to identify cellular neighbourhoods. I will present Positive Ultra-bright Fluorescent Fusion For Identifying Neighbours (PUFFFIN), a new neighbour-labelling system based on the secretion and uptake of a super-positive fluorescent protein. PUFFFIN enables precise and rapid identification, isolation, and profiling of neighbouring cells, even capturing transient interactions. Its modular design allows colour-of-choice labelling and transgene integration, making it highly versatile. I will also demonstrate how we are using PUFFFIN to study coordination of differentiation in mouse embryonic stem cells. This powerful tool offers a simple, sensitive, and customisable approach for profiling cell-cell communication in diverse contexts, paving the way for new insights into cellular interactions.

Letztmalig verändert: 04.02.2025, 07:37:47

Veranstaltungsort

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG CBG Galleria II (VC))Pfotenhauerstraße10801307Dresden
Telefon
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de

Veranstalter

Max Planck Institute of Molecular Cell Biology and GeneticsPfotenhauerstraße10801307Dresden
Telefon
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de
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