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UID:DSC-21654
DTSTART;TZID=Europe/Berlin:20250206T111000
SEQUENCE:1738823766
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20250206T121000
URL:https://dresden-science-calendar.de/calendar/de/detail/21654
LOCATION:IFW\, Helmholtzstraße 2001069 Dresden
SUMMARY:Mirhajivarzaneh: Microscale resonator and shimming system for micro
 fluidic-based nuclear magnetic resonance spectroscopy
CLASS:PUBLIC
DESCRIPTION:Speaker: Alaleh Mirhajivarzaneh\nInstitute of Speaker: IFW Dres
 den\nTopics:\n\n Location:\n  Name: IFW (HSZ/301/U\, TU Dresden)\n  Street
 : Helmholtzstraße 20\n  City: 01069 Dresden\n  Phone: \n  Fax: \nDescript
 ion: Over the past few decades\, efforts to miniaturize Nuclear Magnetic R
 esonance (NMR) spectroscopy have resulted in the down-scaling of the core 
 of the NMR system to microscale detectors or resonators. This achievement 
 has unfolded a new era of NMR spectroscopy\, with applications in biologic
 al and chemical analysis\, where the sample size can scale down to micro- 
 or nanoliters\, typical of microorganisms and cell cultures.  This thesis 
 presents a comprehensive study on optimizing the performance of a previous
 ly developed microresonator\, specifically the self-assembled rolled-up mi
 crocoil\, for NMR spectroscopy. The optimization process involved the impr
 ovement of the sensitivity\, notably achieving a 37.3% increase in SNR for
  samples with a resistance of 2.8 D. Moreover\, a new microfluidic system 
 was developed to replace the previous PDMS-based system\, which introduced
  parasitic effects in the NMR measurements. A crucial advantage of this no
 vel system is its adaptability to different resin-based materials\, result
 ing in a more efficient and versatile device.  Furthermore\, the microcoil
  was used for the analysis of two biological analytes\; oocyte media and b
 lood plasma. This investigation provided valuable insights into the practi
 cal limits of detection for this technology and helped to identify prospec
 tive directions for future research and applications.  Magnetic shimming i
 s a widely used technique for homogenizing NMR magnetic fields. However\, 
 the benefits of miniaturizing these systems can be substantial\, particula
 rly in addressing the inhomogeneities encountered in experiments with micr
 oresonators. Additionally\, miniaturization contributes to reducing both s
 ize and cost. A significant innovation introduced in this work is the desi
 gn and implementation of a microscale shimming system for the first time t
 ailored to the specification of the 3D microcoil. This magnetic shimming s
 ystem\, developed using similar fabrication techniques to the microcoil\, 
 achieved a 15% reduction in the average linewidth compared to the control 
 experiments using shimming coils with no current applied. This achievement
  opens up new possibilities for further exploration and optimization\, pot
 entially broadening the scope of applications and enhancing the performanc
 e of microscale NMR coils.
DTSTAMP:20260421T063419Z
CREATED:20250118T063631Z
LAST-MODIFIED:20250206T063606Z
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