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UID:DSC-21958
DTSTART;TZID=Europe/Berlin:20250512T130000
SEQUENCE:1747028372
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20250512T140000
URL:https://dresden-science-calendar.de/calendar/de/detail/21958
LOCATION:TUD CRTD\, Fetscherstraße 10501307 Dresden
SUMMARY:CMCB Extraordinary Seminar: Prof. Kirsten Sadler\, New York Univers
 ity Abu Dhabi\, United Arab Emirates
CLASS:PUBLIC
DESCRIPTION:Speaker: \nInstitute of Speaker: \nTopics:\nBiologie\, Willkomm
 en\n Location:\n  Name: TUD CRTD ()\n  Street: Fetscherstraße 105\n  City
 : 01307 Dresden\n  Phone: +49 (0)351 458 82052\n  Fax: +49 (0)351 458 8205
 9 \nDescription: <p><strong>Host:</strong> Nikolay Ninov (CRTD)</p> <p><st
 rong>Title: </strong>“Epigenetic regulation of regeneration: From mouse 
 livers to Octopus limbs.”</p> <p><strong>Abstract: </strong>Highly regen
 erative tissues are epigenetically primed to rapidly activate genes that c
 ontrol proliferation. We hypothesized that an epigenetic code underlies th
 is priming in the mouse liver and found that many cell cycle genes exhibit
  a distinct epigenetic signature in the uninjured state\, a pattern that i
 s disrupted upon mutation of the epigenetic regulator UHRF1. Interestingly
 \, manipulation of UHRF1 in zebrafish produces markedly different cellular
  outcomes compared to mice\, though the mechanisms underlying these specie
 s-specific differences remain unclear. Extending this work to cephalopods\
 , we are investigating the octopus arm\, a continually regenerating struct
 ure.  Foundational work in studying regeneration in a non-model organism 
 is underway and providing insight into the gene and transposon regulation 
 mechanisms in this species.</p>
DTSTAMP:20260511T204447Z
CREATED:20250429T054012Z
LAST-MODIFIED:20250512T053932Z
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