Bi

Quantifying intracellular mechanics by a mechanical fingerprint and a new observable to detected broken detailed balance

Datum
19.06.2025
Zeit
11:00 - 12:00
Sprecher
Timo Betz
Zugehörigkeit
Faculty of Physics, Georg-August-Universität, Göttingen
Serie
MPI-CBG Thursday Seminar
Sprache
en
Hauptthema
Biologie
Host
Ricard Alert
Beschreibung
Many biological systems rely on fundamental physical principles for their proper function. Mechanical processes such as force generation, and the adaptation of stiffness and viscosity, have been successfully applied to address complex biomedical questions using physical concepts. These advances have been driven largely by innovative methods that enable the quantification of biological processes and the development of theoretical models with high predictive power. In this presentation, I will discuss our recent approaches for studying active force generation and mobility across various biological systems and length scales. Beginning with an overview of the challenges in mechanical measurements at the micro- and nanoscale within living systems, I will highlight examples where these methods have successfully explained the motion of particles inside living cells, the physical fluidization of the cytosol during cell division, and the development of mechanical fingerprints to classify different cell types. To extend this framework, we introduce a novel observable called the mean-back relaxation. This measure, related to the well-known mean squared displacement, offers the unique ability to detect non-equilibrium processes and broken detailed balance even in scenarios where traditional trajectory-based analyses fail to capture non-equilibrium components. We demonstrate that this quantity provides a robust measure of activity, both in controlled experimental setups and in complex materials such as living cells.

Letztmalig verändert: 19.06.2025, 07:37:08

Veranstaltungsort

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG CBG Large Auditorium)Pfotenhauerstraße10801307Dresden
Telefon
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de

Veranstalter

Max Planck Institute of Molecular Cell Biology and GeneticsPfotenhauerstraße10801307Dresden
Telefon
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de
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