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BEGIN:VEVENT
UID:DSC-22005
DTSTART;TZID=Europe/Berlin:20251127T110000
SEQUENCE:1764225540
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20251127T120000
URL:https://dresden-science-calendar.de/calendar/de/detail/22005
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Lánský: ATP regulates tau-microtubule interaction
CLASS:PUBLIC
DESCRIPTION:Speaker: Zdeněk Lánský\nInstitute of Speaker: BIOCEV Prague\
 , Czechia\nTopics:\n\n Location:\n  Name: MPI-CBG (MPI-CBG CBG Large Audit
 orium)\n  Street: Pfotenhauerstraße 108\n  City: 01307 Dresden\n  Phone: 
 +49 351 210-0\n  Fax: +49 351 210-2000\nDescription: Neuronal microtubule-
 associated protein tau can protect the microtubule surface\, maintaining m
 icrotubule stability. In neurodegenerative diseases termed tauopathies\, t
 au forms cyto-toxic aggregates presumably as a consequence of tau delocali
 zation from microtubules\, accompanied by an increase in cytoplasm-localiz
 ed tau and microtubule destabilization. The underlying mechanisms\, howeve
 r\, remain unclear. Here\, we show that decline of adenosine triphosphate 
 (ATP)\, related to aging and neurodegeneration\, leads to tau delocalizati
 on from microtubules and microtubule disintegration. Combining reconstitut
 ion experiments with molecular modeling\, we show that ATP stabilizes tau 
 molecules on the microtubule surface through electrostatic interactions. W
 e propose that pathological decline of ATP can destabilize microtubule-tau
  interactions and lead to an increase of cytoplasmic tau\, providing a pla
 usible functional link between ATP homeostasis and tauopathies.
DTSTAMP:20260409T101947Z
CREATED:20250516T053718Z
LAST-MODIFIED:20251127T063900Z
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