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UID:DSC-22061
DTSTART;TZID=Europe/Berlin:20250612T110000
SEQUENCE:1749706541
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20250612T120000
URL:https://dresden-science-calendar.de/calendar/de/detail/22061
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Weijers: Evolutionary biochemistry to trace the origins and mechani
 sms of cellular signaling
CLASS:PUBLIC
DESCRIPTION:Speaker: Dolf Weijers\nInstitute of Speaker: Laboratory of Bioc
 hemistry\, Wageningen University\, Netherlands\nTopics:\n\n Location:\n  N
 ame: MPI-CBG (MPI-CBG CBG Large Auditorium)\n  Street: Pfotenhauerstraße 
 108\n  City: 01307 Dresden\n  Phone: +49 351 210-0\n  Fax: +49 351 210-200
 0\nDescription: The behavior of cells is dictated by a multitude of signal
 s\, and response mechanisms interpret these signals and define cellular ou
 tput. While there is a relatively detailed understanding of the mechanisms
  that perceive\, relay and transduce signals in model organisms\, it is of
 ten poorly understood how these originated and evolved. As a consequence\,
  it is nearly impossible in any extant organism to define which properties
  of a signaling system are ancestral and which represent specialized\, der
 ived features. All cellular signaling\, complex or simple\, originated fro
 m the assembly of multiple components into a pathway. In my talk\, I will 
 show how an evolutionary biochemistry approach can not only reveal the ori
 gin and evolution of a signaling pathway\, but also identify its core desi
 gn principles and inspire the discovery of new response pathways. I will u
 se examples from our ongoing research program on the plant signaling molec
 ule auxin and show how the use of comparative phylogenetic strategies\, co
 mbined with mechanistic\, genetic and biochemical analysis within a simple
  model system\, allows to reconstruct the origin and evolution of a comple
 x signaling system. I will also show how evolutionary innovations in trans
 cription factors have led to the emergence of a competition-based system o
 f nuclear protein condensates. Lastly\, I will show how – through an evo
 lutionary lens – we have discovered a deeply conserved\, ancient\, yet u
 nsuspected auxin response system that urges questions about the ancestral 
 function of this signaling molecule.
DTSTAMP:20260511T211308Z
CREATED:20250611T053703Z
LAST-MODIFIED:20250612T053541Z
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