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UID:DSC-22370
DTSTART;TZID=Europe/Berlin:20251016T150000
SEQUENCE:1760592947
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20251016T154500
URL:https://dresden-science-calendar.de/calendar/de/detail/22370
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Hoekzema: Spectral gene selection methods and models for host/paras
 ite co-phylogeny
CLASS:PUBLIC
DESCRIPTION:Speaker: Renee Hoekzema\nInstitute of Speaker: Vrije Universite
 it Amsterdam\nTopics:\n\n Location:\n  Name: MPI-CBG (MPI-CBG CSBD SR Grou
 nd Floor (VC))\n  Street: Pfotenhauerstraße 108\n  City: 01307 Dresden\n 
  Phone: +49 351 210-0\n  Fax: +49 351 210-2000\nDescription: I will talk a
 bout two disjoint projects. Firstly\, I will talk about an application of 
 spectral graph theory to the study of single cell transcriptomics\, in par
 ticular the problem of feature selection of relevant genes in such experim
 ents. Single cell transcriptomics is a powerful technique in biology that 
 allows for the measurement of gene expression levels in many individual ce
 lls simultaneously. Current methods for analysis assume that cell types ar
 e discrete. However\, in practice there is also continuous variation betwe
 en cells: subtypes of subtypes\, differentiation pathways\, responses to e
 nvironment or treatment\, et cetera. We propose topologically-inspired dat
 a analysis methods that identify coherent gene expression patterns conside
 ring discrete and continuous patterns on equal footing. This is joint work
  with Lewis Marsh\, Otto Sumray\, Thomas Carroll\, Xin Lu\, Helen Byrne an
 d Heather Harrington. Secondly\, I will talk about ongoing work with Gilli
 an Grindstaff on models for co-evolution of “nested’’ systems\, such
  as parasite/host systems\, individuals within a species\, or “phylosymb
 iosis” – the coupled evolution of the microbiome and its hosts. We cre
 ate a space of nested phylogenetic trees and study its intricate geometry.
  In particular we show that this space is CAT(0) – in analogy with the i
 nfluential work of Billera\, Holmes and Vogtmann (2001) – implying the e
 xistence of unique averages over nested trees.
DTSTAMP:20260421T180458Z
CREATED:20251008T053744Z
LAST-MODIFIED:20251016T053547Z
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