Engineering the Chemistry of Cellular Membranes

Datum

26.05.2026

Zeit

15:00 - 16:00

Sprecher

Jeremy Baskin

Zugehörigkeit

Department of Chemistry and Chemical Biology and Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York, USA

Sprache

en

Hauptthema

Biologie

Host

André Nadler

Beschreibung

Cellular membranes are dynamic chemical systems whose lipid composition is tightly regulated across space and time, yet the mechanisms governing lipid metabolism, transport, and function remain incompletely understood. I will describe our eKorts in synthetic lipid biology to develop chemical and optogenetic approaches for interrogating membrane function in living cells. These include activity-based imaging strategies for visualizing lipid metabolism and transport, photoaKinity lipid probes for mapping lipid interactomes and uncovering hidden biological functions, and optogenetic membrane editing technologies that enable rapid and spatially precise manipulation of membrane lipid composition. By integrating these approaches with proximity labeling, chemoproteomics, and advanced imaging, we are beginning to reveal new mechanisms governing lipid homeostasis, inter-organelle communication, and the spatiotemporal organization of membrane metabolism and transport. More broadly, these studies highlight how engineered chemical tools can provide new insight into the architecture and function of cellular membranes.

Letztmalig verändert: 26.05.2026, 07:36:16