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UID:DSC-23017
DTSTART;TZID=Europe/Berlin:20260707T140000
SEQUENCE:1783402802
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20260707T150000
URL:https://dresden-science-calendar.de/calendar/de/detail/23017
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Plum: Positional information and information flows in dynamic tissu
 es
CLASS:PUBLIC
DESCRIPTION:Speaker: Alexander Plum\nInstitute of Speaker: UCSD\, San Diego
 \, USA\nTopics:\n\n Location:\n  Name: MPI-CBG (MPIPKS\, Room 1D1)\n  Stre
 et: Pfotenhauerstraße 108\n  City: 01307 Dresden\n  Phone: +49 351 210-0\
 n  Fax: +49 351 210-2000\nDescription: During development\, embryos store\
 , transmit\, and transform information to generate spatial patterns. Posit
 ional information (PI) quantifies how precisely cells form patterns at a g
 iven time\, but cell motion has limited its application to static tissues.
  We introduce a framework for PI in dynamic tissues by decomposing mutual 
 information between cells’ positions and properties over time into infor
 mation flows contributing to PI preservation\, loss and generation. These 
 reveal information-theoretic signatures of ubiquitous developmental proces
 ses\, including instruction\, sorting and mixing\, directly from data. App
 lying this framework to whole-embryo cell trajectories in Drosophila\, mou
 se and zebrafish gastrulation\, we provide local and global information-th
 eoretic quantification of cell mixing and derive bounds on PI preservation
  imposed by tissue dynamics. We further show that morphogenesis structures
  mixing\, preferentially preserving specific patterns. Finally\, we derive
  inequality conditions for tracing generated PI to candidate information s
 ources and distinguishing among alternative pattern-formation mechanisms\,
  from programmed extracellular cues to self-organizing intercellular inter
 actions.
DTSTAMP:20260906T095513Z
CREATED:20260702T053820Z
LAST-MODIFIED:20260707T054002Z
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