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UID:DSC-23041
DTSTART;TZID=Europe/Berlin:20260922T110000
SEQUENCE:1789623396
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20260922T120000
URL:https://dresden-science-calendar.de/calendar/de/detail/23041
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Tchorz: Game of zones: WNTer is coming
CLASS:PUBLIC
DESCRIPTION:Speaker: Jan S. Tchorz\nInstitute of Speaker: Institute of Phys
 iology\, University of Tübingen\, Germany\nTopics:\n\n Location:\n  Name:
  MPI-CBG (MPI-CBG CBG Large Auditorium)\n  Street: Pfotenhauerstraße 108\
 n  City: 01307 Dresden\n  Phone: +49 351 210-0\n  Fax: +49 351 210-2000\nD
 escription: Complex organ function arises from spatially coordinated cell 
 identities. Liver function depends on segregated metabolic programs along 
 the porto-central axis. How this spatial logic and multicellular dynamics 
 are disrupted in human chronic liver disease (CLD) remains unknown. By com
 bining complex lineage tracing in mice and multimodal spatial transcriptom
 ics in patients\, we show that CLD across diverse etiologies is defined by
  a global collapse of metabolic zonation. Using spatial neighborhood analy
 ses\, we develop an entropy-based framework that quantitatively captures d
 isruption of metabolic order and multicellular dynamics across three CLD e
 tiologies. Mechanistically\, impaired zonated WNT/β-catenin signaling dri
 ves loss of pericentral metabolism\, whereas ectopic enrichment of WNT/RSP
 O ligands within injury niches induces transient metabolic reprogramming a
 nd hepatocyte plasticity during regeneration. YAP signaling promotes hepat
 ocyte proliferation and induces biliary metaplasia in periportal hepatocyt
 es\, but therapeutic targeting of the pathway fails to restore liver regen
 eration following extended hepatectomy. Together\, these findings demonstr
 ate that hepatocyte identity and zonation are fundamentally fluid. Restori
 ng functional tissue in chronic liver failure requires looking beyond stat
 ic cell populations to target the underlying spatial signaling architectur
 es that constrain aberrant plasticity and license productive organ regener
 ation.
DTSTAMP:20260918T012412Z
CREATED:20260716T054009Z
LAST-MODIFIED:20260917T053636Z
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