Semantic Similarity in Biomedical Ontologies: measurement, assessment and applications

Datum

28.09.2012

Zeit

11:00 - 12:00

Sprecher

Dr. Francisco Couto

Zugehörigkeit

University Lisbon, Faculty of Science

Sprache

en

Hauptthema

Biologie

Andere Themen

Biologie

Host

Michael Schroeder

Beschreibung

The analysis of complex biomedical entities and events, such as disease and epidemiological models, is challenging due to their multiple domain features, and thus to accurately describe them we need to use concepts from multiple biomedical ontologies, such as gene mutations, protein functions, anatomical parts and phenotypes. The usefulness of ontological annotations to interlink and interpret biomedical information is widely recognized, particularly for retrieving related information. This relatedness can be captured by semantic similarity measures that return a numerical value reflecting the closeness in meaning between two ontology concepts or two annotated entities. These measures have been successfully applied to biomedical ontologies, particularly to the Gene Ontology, for comparing proteins based on the similarity of their functions. This talk will discuss ongoing efforts to calculate semantic similarity, describe popular techniques used to calculate their effectiveness, and present existing biomedical applications that use semantic similarity measures to improve their performance.

Letztmalig verändert: 10.09.2012, 18:12:17