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UID:DSC-4087
DTSTART;TZID=Europe/Berlin:20121026T110000
SEQUENCE:1351236913
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20121026T120000
URL:https://dresden-science-calendar.de/calendar/de/detail/4087
LOCATION:TUD CRTD\, Fetscherstraße 10501307 Dresden
SUMMARY:Ross: Recent advances in regulation of Osteoclast Formation and Fun
 ction
CLASS:PUBLIC
DESCRIPTION:Speaker: Dr. F. Patrick Ross\nInstitute of Speaker: \nTopics:\n
 Biologie\, Medizin\n Location:\n  Name: TUD CRTD (CRTD\, Auditorium left)\
 n  Street: Fetscherstraße 105\n  City: 01307 Dresden\n  Phone: +49 (0)351
  458 82052\n  Fax: +49 (0)351 458 82059 \nDescription:     My research foc
 used on the molecular mechanisms by which osteoclasts     are generated an
 d resorb bone. I have used extensively the power of     mouse genetics to 
 achieve these goals\, taking as a starting point in     most instances ani
 mals with an in vivo bone phenotype associated     with osteoclast dysfunc
 tion and\, wherever possible\, relevant to     human disease.  We performe
 d in vivo analysis of bone phenotype\,     complemented by in vitro cultur
 e studies of authentic osteoclast     precursors\, deleted of specific gen
 es and consistently rescued the     phenotype by retrovital transduction o
 f wild type and mutant genes     in null precursors.  Our assays involved\
 , micro CT\, dynamic     histomorphometry\, dissection of signaling pathwa
 ys and examination     of changes in the actin cytoskeleton\, all assessed
  in conjunction     with resorption of authentic bone.  These studies have
  led to     increased understanding of how individual proteins and point  
    mutations thereof regulation survival and proliferation of     osteocla
 st precursors and their differentiation and function.    
DTSTAMP:20260502T184039Z
CREATED:20121024T073514Z
LAST-MODIFIED:20121026T073513Z
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