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UID:DSC-6345
DTSTART;TZID=Europe/Berlin:20131127T130000
SEQUENCE:1385537826
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20131127T140000
URL:https://dresden-science-calendar.de/calendar/de/detail/6345
LOCATION:BioZ\, Tatzberg 47-4901307 Dresden
SUMMARY:Kwok: Aggregation of chondroitin sulphate proteoglycans into perine
 uronal nets control plasticity in the adult central nervous system
CLASS:PUBLIC
DESCRIPTION:Speaker: Jessica Kwok\, John van Geest Centre for Brain Repair 
 Cambridge\nInstitute of Speaker: \nTopics:\nBiologie\n Location:\n  Name: 
 BioZ (BIOTEC\, Seminar room 3rd floor)\n  Street: Tatzberg 47-49\n  City: 
 01307 Dresden\n  Phone: \n  Fax: \nDescription: The glial scar that forms 
 after a CNS injury contains molecules that are inhibitory to axon. The up-
 regulation of these molecules\, which normally help to maintain stable con
 nections and ensure proper functions of the CNS\, in the glial scar hinder
 s the CNS from recovery. One of the key inhibitory molecules presents in t
 he glial scar is chondroitin sulphate proteoglycans (CSPGs). Enzymatic rem
 oval of the CSPGs in the lesion area enhances both structural and function
 al recovery in the CNS. Apart from enhancing regeneration\, we recently di
 scover that removing CSPGs around the lesion core re-activates plasticity\
 , a process which allows re-routing of neural pathways and connections. Th
 is increase in plasticity is mainly attributed to the removal of CSPGs in 
 a structure called perineuronal nets (PNNs). PNNs are mainly composed of C
 SPGs\, hyaluronan\, link proteins\, and tenascin R. In contrast to the loo
 se extracellular matrix present in the brain\, the supramolecular interact
 ions between these molecules lead to the formation of a compact pericellul
 ar complex which surrounds synapses on the neuronal surface. We have devel
 oped an in vitro model for the PNNs and identified the key molecules invol
 ved in the formation of the PNNs. Knocking out these molecules reverts the
  compact matrix into loose extracellular matrix. Transgenic mice with atte
 nuated PNNs\, due to a lack of molecular aggregation\, showed enhanced pla
 sticity and regeneration. We are currently looking into methods to manipul
 ate the extracellular matrix aggregation which may benefit recovery after 
 CNS injury.
DTSTAMP:20260411T120103Z
CREATED:20131120T073944Z
LAST-MODIFIED:20131127T073706Z
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