Membrane-Spanning DNA Nanopores: Bottom-up Structures for Single-Molecule Research and Nanotechnology

Datum

18.03.2014

Zeit

13:00 - 14:00

Sprecher

Stefan Howorka

Zugehörigkeit

University College London, Department of Chemistry, UK

Serie

TUD nanoSeminar

Sprache

en

Hauptthema

Materialien

Andere Themen

Materialien

Host

G. Cuniberti

Beschreibung

DNA nanotechnology excels at rationally designing functional bottom-up structures. I describe the design and generation of stable self-assembled DNA-based nanopores that insert into lipid bilayers to support transmembrane water flow. The DNA nanopores consist of a bundle of six hexagonally arranged duplexes which are interconnected by cross-overs. The negatively charged nanobarrels carry lipid anchors to facilitate the pores’ insertion into the hydrophobic bilayers. The lipid anchors either neutralize localized negative charges on the DNA backbone (Nano Letters, 2013, 13, 2351) or consist of few, large hydrophobic groups (Angew Chem Int Ed, 2013, 52, 12069). The small membrane-spanning DNA pores merge the fields of nanopores and DNA-nanotechnology and will help open up the design of entirely new molecular devices for applications within single-molecule research and sensing, electric circuits, catalysis, and nanofluidics.

Letztmalig verändert: 18.03.2014, 08:42:08