Dynamic nuclear polarization of biomolecules: a physical perspective

Datum

16.06.2014

Zeit

15:00 - 16:00

Sprecher

Dr. Marta Filibian

Zugehörigkeit

Department of Physics, University of Pavia

Sprache

en

Hauptthema

Materialien

Andere Themen

Materialien, Physik

Host

Christine Malbrich

Beschreibung

abstract Dynamic Nuclear Polarization (DNP) is one of the most effective ways to attain a giant nuclear hyperpolarization and is based on the polarization transfer from the electron to the nuclear spins occurring under irradiation of the Electron Spin Resonance spectrum with microwaves. DNP allows to perform Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) of low sensitivity nuclei with a dramatic enhancement, as high as 10000, of the signal to noise ratio. In preclinical research the recent development of dissolution-DNP has boosted relevant advances in the metabolic imaging of 13C enriched endogenous molecules, injected in animal models after previous hyperpolarization and dissolution. However, for decades many crucial aspects of the complex DNP phenomenon have remained unexplained by the available theoretical models. In order to clarify the physical processes involved in DNP of biomolecules the results of a recent NMR investigation will be presented. It will be shown that the polarization and relaxation properties of these molecules can be sensibly tuned by varying several parameters such as the lattice properties, temperature, the concentration of nuclei and the concentration of paramagnetic radicals. The potential impact of these findings on the development of theoretical DNP models based on rate equations approaches and on the biomedical or solid state applications will be discussed.

Links

• Seminars at the IFW

Letztmalig verändert: 16.06.2014, 09:48:43