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UID:DSC-750
DTSTART;TZID=Europe/Berlin:20110503T110000
SEQUENCE:1303230128
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20110503T120000
URL:https://dresden-science-calendar.de/calendar/de/detail/750
LOCATION:TUD Andreas-Pfitzmann-Bau\, Nöthnitzer Straße 4601069 Dresden
SUMMARY:Walther: Cell Cycle Associated Metabolic Regulation during Meiotic 
 Development in Yeast
CLASS:PUBLIC
DESCRIPTION:Speaker: Thomas Walther\nInstitute of Speaker: Universität Tou
 louse\, Frankreich\nTopics:\nBiologie\n Location:\n  Name: TUD Andreas-Pfi
 tzmann-Bau (1096)\n  Street: Nöthnitzer Straße 46\n  City: 01069 Dresden
 \n  Phone: \n  Fax: \nDescription: The meiotic cell cycle facilitates tran
 sformation of vegetative yeast cells into spores that ensure long-term sur
 vival\, and recombination of the parental DNA to create genetic diversity.
  Our study focused on the metabolic regulation of meiotic development and 
 incorporated information on expression levels and activities of enzymes in
  the central metabolism\, together with metabolome data of the correspondi
 ng pathways. The metabolic make-up of the cells exhibited strong temporal 
 compartmentalisation during meiotic development\, thereby satisfying chang
 ing energetic and anabolic needs during different cell-cycle stages. Metab
 olic reprogramming was enabled by meiosis-specific regulation of approxima
 tely one third of the 26 monitored enzymatic activities. The inactivation 
 of both\, phosphofructokinase and NAD-dependent glutamate dehydrogenase\, 
 and glycogen mobilisation were related to cell cycle progression. The corr
 elation between transcript levels and enzymatic activities of most enzymes
  was poor during meiotic development\, and completely lost for the majorit
 y of the glycolytic enzymes during the meiotic divisions. In addition\, it
  was shown that functioning of the Amd1/Isn1 system responsible for the ho
 meostasis of energy bearing nucleotides was vital for the execution of mei
 otic differentiation. Our study demonstrated a tight correlation of metabo
 lic regulation and cell cycle progression\, and provided a reference to ch
 aracterise the impact of metabolic perturbations on meiotic development.
DTSTAMP:20260525T062814Z
CREATED:20110419T162208Z
LAST-MODIFIED:20110419T162208Z
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