Going Round in Circles: Development of The Zebrafish Vestibular System

Datum

20.06.2014

Zeit

11:00 - 12:00

Sprecher

Dr. Tanya Whitfield, Bateson Centre, Department of Biomedical Science, University of Sheffield

Serie

CMCB Life Sciences Seminar

Sprache

en

Hauptthema

Biologie

Andere Themen

Biologie, Medizin

Host

Michael Brand

Beschreibung

Dr. Whitfield about her research: My research programme aims to understand the development of the zebrafish inner ear, the organ of hearing and balance. We work on axial and regional patterning of the otic vesicle, morphogenesis of the semicircular canals and formation of the otoliths, using a range of genetic, chemical, imaging and behavioural approaches. My talk will concentrate on the developing vestibular (balance) system. We have identified a GPCR with a role in the fusion of epithelial sheets during semicircular canal formation. We have also identified two glycoprotein components of the zebrafish otolithic membrane: these are highly conserved with components of the mammalian otoconial membrane that underlie some forms of human deafness and vestibular disease. Publications:Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene. Geng FS, Abbas L, Baxendale S, Holdsworth CJ, Swanson AG, Slanchev K, Hammerschmidt M, Topczewski J, Whitfield TT. Development. 2013 Nov;140(21):4362-74. doi: 10.1242/dev.098061. Epub 2013 Sep 25.PMID:24067352The role of hair cells, cilia and ciliary motility in otolith formation in the zebrafish otic vesicle. Stooke-Vaughan GA, Huang P, Hammond KL, Schier AF, Whitfield TT. Development. 2012 May;139(10):1777-87. doi: 10.1242/dev.079947. Epub 2012 Mar 29.PMID:22461562Fgf and Hh signalling act on a symmetrical pre-pattern to specify anterior and posterior identity in the zebrafish otic placode and vesicle. Hammond KL, Whitfield TT. Development. 2011 Sep;138(18):3977-87. doi: 10.1242/dev.066639. Epub 2011 Aug 10.PMID:21831919Nkcc1 (Slc12a2) is required for the regulation of endolymph volume in the otic vesicle and swim bladder volume in the zebrafish larva. Abbas L, Whitfield TT. Development. 2009 Aug;136(16):2837-48. doi: 10.1242/dev.034215.PMID:19633174Mutations affecting development of the zebrafish inner ear and lateral line. Whitfield TT, Granato M, van Eeden FJ, Schach U, Brand M, Furutani-Seiki M, Haffter P, Hammerschmidt M, Heisenberg CP, Jiang YJ, Kane DA, Kelsh RN, Mullins MC, Odenthal J, Nüsslein-Volhard C. Development. 1996 Dec;123:241-54.PMID: 9007244

Links

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Letztmalig verändert: 20.06.2014, 09:38:21