Retina regeneration in zebrafish

Datum

16.10.2015

Zeit

11:00 - 12:00

Sprecher

Prof. Dan Goldman, University of Michigan, Ann Arbor, USA, Department of Biological Chemistry, Molecular and Behavioral Neuroscience

Sprache

en

Hauptthema

Biologie

Andere Themen

Biologie, Medizin

Host

Michael Brand

Beschreibung

Abstract: Disease or injury to the mammalian retina often leads to gliosis and irreparable vision loss. In contrast, the zebrafish retina responds to injury by regenerating lost neurons and recovering visual responses. Key to this successful regeneration are Müller glia that undergo a reprogramming event so they acquire stem cell characteristics and generate a proliferating population of retinal progenitors that regenerate all major retinal cell types. Our studies have identified secreted factors, signal transduction cascades, epigenetic events and gene expression programs that are necessary for Müller glia reprogramming, proliferation and neuronal regeneration. Recent studies have identified strategies for stimulating Müller glia reprogramming and proliferation in the uninjured retina and have identified secreted factors that contribute to Müller glia quiescence. Our studies suggest Müller glia respond differently to pro-regenerative stimuli in the uninjured and injured retina. It is anticipated that by uncovering the mechanisms regulating Müller glia reprogramming and retina regeneration in zebrafish we will be better equipped to suggest strategies for stimulating retina regeneration in mammals. Publications: Goldman, D. Muller glial cell reprogramming and retina regeneration. Nature Rev Neurosci 2014; 15:431-442. Zhao, X-F., Wan, J., Powell, C. Ramachandran, R., Myers, M.G. and Goldman, D. Leptin and IL-6 family cytokines synergize to stimulate Muller glia reprogramming and retina regeneration. Cell Reports 2014; 9:285–297. Wan, J., Zhao, X-F., Vojtek, A. and Goldman, D. Retinal injury, growth factors and cytokines converge on b-catenin and pStat3 signaling to stimulate retina regeneration. Cell Reports 2014; 9: 272–284. Powell, C., Grant, A. R., Cornblath, E. and Goldman, D. Analysis of DNA methylation reveals a partial reprogramming of the Muller glia genome during retina regeneration. Proc Natl Acad Sci USA 2013; 110:19814-19819. Ramachandran, R., Zhao, X-F. and Goldman, D. Insm1a-mediated gene repression is essential for the formation and differentiation of Muller glia-derived progenitors in the injured retina. Nature Cell Biol, 2012; 14:1013-1023.

Links

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Letztmalig verändert: 16.10.2015, 10:03:37