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UID:DSC-12327
DTSTART;TZID=Europe/Berlin:20170120T110000
SEQUENCE:1484985133
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20170120T120000
URL:https://dresden-science-calendar.de/calendar/en/detail/12327
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Bergeron-Sandoval: Clathrin-mediated endocytosis is driven by conta
 ct adhesion of a phase-separated protein body
CLASS:PUBLIC
DESCRIPTION:Speaker: Louis Bergeron-Sandoval\nInstitute of Speaker: Univers
 ity of Montreal\, Canada\nTopics:\nBiologie\n Location:\n  Name: MPI-CBG (
 Seminar room Galleria)\n  Street: Pfotenhauerstraße 108\n  City: 01307 Dr
 esden\n  Phone: +49 351 210-0\n  Fax: +49 351 210-2000\nDescription: Progr
 ession of clathrin-mediated endocytosis (CME) in yeast\, in absence of tur
 gor and F-actin polymerization\, constitutes an elusive mechanism. We post
 ulated that the condensation of PrD-containing proteins on cortical sites 
 forms\, through protein phase separation\, a viscoelastic body capable of 
 bending the plasma membrane in this context. With imaging and micro rheolo
 gical techniques\, we confirmed that a group of disordered proteins\, that
  coalesce on cortical sites\, are assembled through phase separation into 
 nanometer sized viscoelastic bodies. When these cortical bodies are nuclea
 ted between the membrane and cytoplasm\, new adhesive interfaces are creat
 ed and we propose - through a biophysical model - that free energy availab
 le at these interfaces can produce work to deform the surrounding material
 s. Experimental results further corroborated our model predictions and we 
 thus present a novel mechanism that account for deformation of the membran
 e under action of the cortical bodies alone\, when CME progression is deco
 upled from F-actin polymerization.
DTSTAMP:20260519T184509Z
CREATED:20161230T074103Z
LAST-MODIFIED:20170121T075213Z
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