Genome transcription: mechanisms and regulation

Date

Feb 10, 2017

Time

1:00 PM - 2:00 PM

Speaker

Prof. Dr. Patrick Cramer

Affiliation

Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Göttingen

Language

en

Main Topic

Biologie

Other Topics

Biologie, Medizin

Host

Stephan Grill

Description

Abstract: Our laboratory is combining structural biology with functional genomics and computational biology. Gene transcription is the first step in the expression of the genetic information and a focal point for cellular regulation. Our goal is to understand the molecular mechanisms of gene transcription and the principles of genomic regulation in eukaryotic cells. We use integrated structural biology and complementary functional studies to unravel the three-dimensional and functional architecture of large macromolecular complexes involved in transcription. We also develop functional genomics methods and computational approaches to unravel the cellular mechanisms of genomic regulation. These efforts led to a first molecular movie of transcription and provided insights into gene-regulatory cellular networks. Together, these efforts shape the emerging fields of genome biology and molecular systems biology. Our aim is to understand the functional genome as a regulatory network based on the underlying structural and molecular mechanisms. In my talk I will present the latest unpublished data from our efforts.

Links

• to announcement of the organizer

Last modified: Feb 10, 2017, 8:59:53 AM