Cotranscriptional Folding of RNA Nanostructures and Devices

Date

May 29, 2017

Time

4:30 PM - 5:30 PM

Speaker

Prof. Ebbe Sloth Andersen

Affiliation

Aarhus University, Denmark

Language

en

Main Topic

Physik

Other Topics

Physik

Description

RNA nanotechnology has the great potential to allow us to produce well-defined nanostructures and devices inside cells and thus open up a wide range of design opportunities in synthetic biology. To achieve this goal we need to understand the design principles of geometry, folding kinetics and topology that will allow us to genetically encode well-defined RNA nanostructures that self-assemble during the transcription process. We have recently introduced the single-stranded RNA origami method and validated the architecture by transcribing RNA tiles that assemble into lattices of different geometries. I will introduce new software tools that allow interactive design of RNA origami structures using a library of functional modules and new sequence design approaches that allow large structures to be designed. Also I will show our latest progress in developing larger three-dimensional RNA origami structures and functional RNA nanodevices with applications in biosensing and diagnostics.

Last modified: May 29, 2017, 10:00:21 AM