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UID:DSC-13068
DTSTART;TZID=Europe/Berlin:20170623T100000
SEQUENCE:1498290383
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20170623T110000
URL:https://dresden-science-calendar.de/calendar/en/detail/13068
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Daly: Modeling NAFLD and TGFβ-induced Fibrosis in ExVive™ Human 
 Liver Tissue
CLASS:PUBLIC
DESCRIPTION:Speaker: Christine Daly\nInstitute of Speaker: Organovo Inc.\, 
 UK\nTopics:\nBiologie\n Location:\n  Name: MPI-CBG (Seminar Room 3rd floor
 )\n  Street: Pfotenhauerstraße 108\n  City: 01307 Dresden\n  Phone: +49 3
 51 210-0\n  Fax: +49 351 210-2000\nDescription: Non-alcoholic fatty liver 
 disease (NAFLD) is the most common liver disorder with an estimated preval
 ence of over 25% worldwide and is projected to become the leading indicati
 on for liver transplant by 2025. Despite decades of research focused on NA
 FLD\, an effective treatment has yet to be approved. This is due in part t
 o the reliance on cell culture and animal models that present challenges i
 n translation due to limited functional longevity and species differences\
 , respectively.  ExVive™ Human Liver Tissue\, a clinically-translatable 
 in vitro model\, is ideal for studying the effects of drugs on liver disea
 se progression\, regression\, and the mechanisms involved. Here\, we prese
 nt results showing a nutrient overload induction of liver disease and TGF&
 amp\;#946\;-induced fibrosis in ExVive™ Human Liver Tissue. A variety of
  disease-relevant phenotypes including steatosis\, inflammation\, and fibr
 osis can be demonstrated in the model: - Nutrient overload leads to the ac
 cumulation of   lipid droplets in hepatocytes. - Incorporation of Kupffer 
 cells and stimulation induces inflammatory cytokine release. - Chronic exp
 osure to nutrient overload leads to stellate cell activation and fibrosis.
  - Chronic exposure to chemical inducers of fibrosis or TGF&amp\;#946\; st
 imulation leads to stellate cell activation and fibrosis. - A TGF&amp\;#94
 6\;R1 kinase inhibitor effectively blocks TGF&amp\;#946\;-induced fibrosis
 .
DTSTAMP:20260612T173342Z
CREATED:20170615T074147Z
LAST-MODIFIED:20170624T074623Z
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