Defects of the innate immune system in autoinflammation and autoimmunity

Date

Aug 31, 2017 - Sep 1, 2017

Time

8:00 AM - 7:00 PM

Language

en

Main Topic

Medizin

Other Topics

Medizin

Host

Bianca Weißbach

Description

Welcome to the international scientific symposium of the Clinical Research Group 249 ! Thursday, August 31 7:00 – 8:00 Registration 8:00 – 8:30 Angela Rösen-Wolff: Type I interferonopathies in animal models 8:30 – 9:00 Daniel Kastner: Old dogs, new tricks: Pyrin finally comes of age 9:00 – 9:30 Yenan Bryceson: SAMD9L: At the cross-roads of infection, inflammation, and cancer 9:30 – 10:00 Manfred Boehm: Extracellular purine metabolism in inflammation and vasculopathies: Insights from rare inherited diseases 10:00 – 10:30 Gunther Hartmann: Mechanisms of TLR8- and RIG-I-dependent NK cell activation 10:30 – 11:00 Coffee break 11:00 – 11:30 Hiroki Kato: Chronic activation of RIG-I like receptors leads to autoimmune disorders 11:30 – 12:00 Martin Schlee: Immune recognition and tolerance of viral and endogenous RNA 12:00 – 12:30 Andrea Ablasser: Intracellular DNA sensing during infection and disease 12:30 – 13:00 Andrew Jackson: Linking genome instability to innate immunity 13:00 – 14:00 Snacks & refreshments 14:00 – 14:30 Eicke Latz: NLRP3 function is regulated by posttransational modifications 14:30 – 15:00 Andreas Pichlmair: Modulation of innate immune responses by viral ORFs 15:00 – 15:30 Stefan Bauer: Role of RNA modifications in immune tolerance 15:30 – 16:00 Jan Rehwinkel: Z-RNA: A new signal for innate immunity? 16:00 – 16:30 Coffee break 16:30 – 17:00 Dirk Föll: S100 proteins as biomarkers in autoinflammation 17:00 – 17:30 Scott Canna: IL-18 at the intersection of auto- and hyper-inflammation 17:30 – 18:00 Sigrun Hofmann: Influence of caspase-1 variants on proliferation, phagocytosis and cell death in monocytes/macrophages 18:00 – 18:30 Harold Hoffman: Dissecting inflammatory pathways in CAPS 18:30 – 19:00 Mohamed Lamkanfi: Immune regulation of pyrin signaling in FMF 19:00 Lite bites & poster session Friday, September 1 8:00 – 8:30 Registration 8:30 – 9:00 Anna Rubartelli: Mutant proteins and hyperactivation induce stress in monocytes: role in dysregulated IL-1β secretion and inflammation 9:00 – 9:30 Olaf Groß: Role of metabolism in NLRP3 inflammasome activation and anti-cancer effects of Imiquimod 9:30 – 10:00 Stefan Winkler: Enzymatically inactive caspase-1 mediates a proinflammatory phenotype in mice 10:00 – 10:30 Coffee break 10:30 – 11:00 Claudia Günther: Effect of environmental stressors on DNA damage and type I interferon induction in TREX1 deficient patients 11:00 – 11:30 Nan Yan: Immune disorders associated with TREX1 and STING mutations 11:30 – 12:00 Winfried Barchet: For DNA, it's OK, to put cuts and bruises on display 12:00 – 12:30 Axel Roers: What is the origin of the pathogenic cGAS ligand in Trex1 deficient cells? 12:30 – 13:30 Snacks & Refreshments 13:30 – 14:00 Raphaela Goldbach-Mansky: Updates on diagnosis and treatment of IFN-mediated autoinflammatory diseases 14:00 – 14:30 Bénédicte Neven: JAK inhibitors in SAVI and other interferonopathies 14:30 – 15:00 Min Ae Lee-Kirsch: Nucleic acid-induced autoinflammation and autoimmunity 15:00 – 15:15 Closing remarks, end of symposium

Links

• Homepage of the KFO 249

Last modified: Aug 23, 2017, 3:08:43 PM