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UID:DSC-13386
DTSTART;TZID=Europe/Berlin:20170911T150000
SEQUENCE:1505115905
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20170911T160000
URL:https://dresden-science-calendar.de/calendar/en/detail/13386
LOCATION:HZDR\, Bautzner Landstraße 40001328 Dresden
SUMMARY:Drewes: Institutskolloquium (FWP) \"Lactate transport as a target f
 or cancer therapy\"
CLASS:PUBLIC
DESCRIPTION:Speaker: Lester R. Drewes\nInstitute of Speaker: PhD\,Departmen
 t of Biomedical Sciences\, University of Minnesota Medical School Duluth\,
  Duluth\, Minnesota\, USA\nTopics:\nPhysik\n Location:\n  Name: HZDR (L9.3
 /216 - Bibliothek)\n  Street: Bautzner Landstraße 400\n  City: 01328 Dres
 den\n  Phone: \n  Fax: \nDescription: Altered metabolism is a common featu
 re of malignant tumors and associated stromal cells. Through induction of 
 robust glycolysis\, production of lactic acid is enhanced as is synthesis 
 of substrates supporting cell proliferation. To eliminate excess lactic ac
 id\, cells express integral membrane proteins known as monocarboxylic acid
  transporters. Specifically\, MCT1 and MCT4\, two members of the SLC16A fa
 mily\, are induced several fold in cancer cells and often correlate with p
 roliferation\, metastasis and poor patient prognosis. Therefore\, these tr
 ansporters are targets for anticancer agents designed to block or disrupt 
 lactic acid transport and reduce cell growth and viability. Over 300 small
  molecule inhibitors have been synthesized and evaluated in both in vitro 
 and in vivo tumor models to characterize their properties and potential us
 efulness in the cancer field.
DTSTAMP:20260601T041304Z
CREATED:20170901T075833Z
LAST-MODIFIED:20170911T074505Z
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