Cell polarity in pancreas organogenesis
- Date
- Aug 22, 2011
- Time
- 10:00 AM - 11:00 AM
- Speaker
- Gokul Kesavan
- Affiliation
- BIOTEC, TU Dresden
- Language
- en
- Main Topic
- Biologie
- Other Topics
- Biologie, Medizin
- Host
- Lutz Brusch
- Description
- Almost all eukaryotic cells are spatially asymmetric or polarized. Understanding how cells polarize and coordinate tubulogenesis during organ formation is a central question in biology. Tubulogenesis often coincides with cell lineage specification during organ development. To address these fundamental questions, we have studied the functional role of Cdc42 in pancreatic tubulogenesis. Cdc42, a Rho GTPase, was found to be essential for tube formation during pancreas organogenesis, as it is required for establishing apical cell polarity. In addition, the results revealed the essentiality of tubes in providing correct milieu for the progenitor/stem cells to differentiate into organ-specific functional cell types.
Last modified: Aug 11, 2011, 2:09:16 PM
Location
TUD Andreas-Pfitzmann-Bau (Computer Science) (INF 1004)Nöthnitzer Straße4601069Dresden
- Homepage
- https://navigator.tu-dresden.de/etplan/apb/00
Organizer
Center for Information Services and High Performance ComputingZellescher Weg12-1401069Dresden
- Phone
- +49 351 463-35450
- Fax
- +49 351 463-37773
- TUD ZIH
- Homepage
- http://tu-dresden.de/zih
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