Molecular and cellular bases of tissue homeostasis and tumor transformation in the intestine

Date

Jun 5, 2018

Time

11:00 AM - 12:00 PM

Speaker

Vladimir Korinek

Affiliation

IMG, Prague, Czech Republic

Language

en

Main Topic

Biologie

Other Topics

Biologie

Host

DPSX seminar - Pavel Tomancak

Description

The body of a multi-cellular organism is a highly organized structure of cells, tissues and organs. The Wnt pathway, initiated by secreted Wnt proteins, controls a remarkably diverse array of processes that include cell proliferation, differentiation, cell migration, and cell polarity. The epithelial lining of the intestine represents one of the most intensively self-replenishing organs in mammals. With a rate of entire renewal every 3-5 days, this dynamic and organized cell turnover represents an attractive paradigm for tissue maintenance studies. The scientific focus of our laboratory is related to the molecular mechanisms regulating the Wnt pathway output in the intestine. We employ genetically modified mouse models as the main methodological approach. The presentation is dedicated to the functional studies of the Troy and Msx1 genes that were identified as the Wnt pathway target genes in the intestine. In addition, the current concept of molecular mechanisms driving cell renewal and tumor transformation of the intestinal epithelium will be presented.

Last modified: Jun 6, 2018, 9:55:23 AM