BEGIN:VCALENDAR
VERSION:2.0
PRODID:www.dresden-science-calendar.de
METHOD:PUBLISH
CALSCALE:GREGORIAN
X-MICROSOFT-CALSCALE:GREGORIAN
X-WR-TIMEZONE:Europe/Berlin
BEGIN:VTIMEZONE
TZID:Europe/Berlin
X-LIC-LOCATION:Europe/Berlin
BEGIN:DAYLIGHT
TZNAME:CEST
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
DTSTART:19810329T030000
RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=3;BYDAY=-1SU
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:CET
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
DTSTART:19961027T030000
RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=10;BYDAY=-1SU
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
UID:DSC-14245
DTSTART;TZID=Europe/Berlin:20180412T160000
SEQUENCE:1523518830
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20180412T170000
URL:https://dresden-science-calendar.de/calendar/en/detail/14245
LOCATION:TUD CRTD\, Fetscherstraße 10501307 Dresden
SUMMARY:Monville: Preclinical validation of an hESC-retinal epithelial cell
  sheets in rodents and primates
CLASS:PUBLIC
DESCRIPTION:Speaker: Prof. Christelle Monville\nInstitute of Speaker: I-Ste
 m\, INSERM/UEVE UMR861\nTopics:\nBiologie\, Medizin\n Location:\n  Name: T
 UD CRTD (CRTD\, ground floor\, auditorium left)\n  Street: Fetscherstraße
  105\n  City: 01307 Dresden\n  Phone: +49 (0)351 458 82052\n  Fax: +49 (0)
 351 458 82059 \nDescription: Abstract:   Loss of retinal pigmented epithel
 ial (RPE) cells is responsible for severe vision impairments in retinal de
 generative disorders\, such as retinitis pigmentosa. Stem cell-derived RPE
  cells have shown promise as a cell therapy for treating retinal degenerat
 ion in preclinical studies\, but long-term positive outcomes require effic
 ient engraftment and survival of the transplanted cells. Taking a step in 
 this direction\, we have developed a tissue engineered product comprising 
 human embryonic stem cell (hESC)-derived RPE cells that were grown as shee
 ts on a biological scaffold. Transplantation of these hESC-RPE cell sheets
  into a rat model of retinal degeneration resulted in greater cell engraft
 ment and survival and improved visual acuity compared to hESC-RPE cells tr
 ansplanted as cell suspensions. These tissue engineered cell sheets may im
 prove the efficacy of cell therapy for treating retinal degenerative disea
 ses   5 most important publications:  1. Ben M'Barek K\, Habeler W\, Planc
 heron A\, Jarraya M\, Regent F\, Terray A\, Yang Y\, Chatrousse L\, Doming
 ues S\, Masson Y\, Sahel JA\, Peschanski M\, Goureau O\, Monville C. Clini
 cally compatible human ES-derived RPE cells grafted as an epithelium poten
 tiates vision rescue in dystrophic rodent. Sci Transl Med. 2017 Dec 20\;9(
 421).  2. Ben M'Barek K\, Regent F\, Monville C. Use of human pluripotent 
 stem cells to study and treat retinopathies. World J Stem Cells. 2015 Apr 
 26\;7(3):596-604.  3. Reichman S\, Terray A\, Slembrouck A\, Nanteau C\, O
 rieux G\, Habeler W\, Nandrot E\, Sahel JA\, Monville C\, Goureau O. From 
 confluent human iPS cells to self-forming neural retina and RPE cells. PNA
 S. (2014) 111(23):8518-23.  4. Lustremant C\, Habeler W\, Plancheron A\, G
 oureau O\, Grenot L\, de la Grange P\,Audo I\, Nandrot EF\, Monville C. Hu
 man induced pluripotent stem cells as a tool to model a form of Leber cong
 enital amaurosis. Cell Reprogram. (2013) 15(3):233-246  5. Habeler W\, Gha
 leh B \, Barthelemy I\, Plancheron A\, Bizé A\, Carlos-Sampedrano C\, Che
 tboul V\, Berdeaux A\, Pucéat M\, Peschanski M\, Blot S\, Monville C. Dir
 ect myocardial implantation of human embryonic stem cells in a dog model o
 f Duchenne cardiomyopathy reveals poor cell survival in dystrophic tissue.
  JSRM (2011) 7(2): 80-86.
DTSTAMP:20260623T114905Z
CREATED:20180330T075051Z
LAST-MODIFIED:20180412T074030Z
END:VEVENT
END:VCALENDAR