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UID:DSC-15702
DTSTART;TZID=Europe/Berlin:20190612T163000
SEQUENCE:1553776705
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20190612T173000
URL:https://dresden-science-calendar.de/calendar/en/detail/15702
LOCATION:TUD Hörsaalzentrum\, Bergstraße 6401069 Dresden
SUMMARY:Suarez: Interactions of Sperm with the Female Reproductive Tract (M
 icroswimmers lecture series)
CLASS:PUBLIC
DESCRIPTION:Speaker: Susan Suarez\nInstitute of Speaker: Cornell University
 \nTopics:\nBiologie\, Physik\, Mathematik\, Chemie\n Location:\n  Name: TU
 D Hörsaalzentrum (HSZ/E05)\n  Street: Bergstraße 64\n  City: 01069 Dresd
 en\n  Phone: +49 351 463-34457\n  Fax: +49 351 463-32883\nDescription: The
  female reproductive tract interacts with sperm (1) to facilitate sperm mi
 gration to the egg while impeding migration of pathogens into the tract\, 
 (2) to keep sperm alive during the time between mating and ovulation\, (3)
  to prepare sperm for fertilization\, and (4) to select the fittest sperm 
 for fertilization. In humans and cattle\, natural coitus places semen in t
 he vagina at the entrance to the cervix. Sperm must then migrate into and 
 through the cervix\, uterus\, and lower oviduct to reach eggs in the upper
  oviduct. In the cervix\, microgrooves in the walls of the cervical canal\
 , together with the pro-vaginal flow of viscoelastic secretions\, can faci
 litate passage of sperm through the cervix to the uterus. The viscoelastic
 ity of the fluid can induce dynamic collective swimming of sperm\, which m
 ay enhance sperm migration. In the oviduct\, sperm are stored and undergo 
 capacitation (the physiological process that prepares sperm to fertilize e
 ggs). Sperm are stored in the oviduct by binding to its wall via specific 
 interactions between sperm proteins and oviductal receptors. Subsequently\
 , sperm in the reservoir capacitate and release from storage\, and then mi
 grate to the eggs. Release of sperm has been  associated with modification
 s of the protein coating of sperm and hyperactivation of sperm movement. A
 s released sperm swim freely\, pro-uterine fluid flow can orient them to s
 wim toward the upper oviduct\, but there is also evidence that intermitten
 t contractions can rapidly push groups of sperm up the oviduct. Finally\, 
 hyperactivation of sperm swimming can enhance migration through oviductal 
 mucus and the viscoelastic matrices of the cumulus oophorus and zona pellu
 cida that surround the egg. Altogether\, such interactions of sperm with t
 he female tract act to promote the success of fertilization.
DTSTAMP:20260507T084248Z
CREATED:20190226T122059Z
LAST-MODIFIED:20190328T123825Z
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