BEGIN:VCALENDAR
VERSION:2.0
PRODID:www.dresden-science-calendar.de
METHOD:PUBLISH
CALSCALE:GREGORIAN
X-MICROSOFT-CALSCALE:GREGORIAN
X-WR-TIMEZONE:Europe/Berlin
BEGIN:VTIMEZONE
TZID:Europe/Berlin
X-LIC-LOCATION:Europe/Berlin
BEGIN:DAYLIGHT
TZNAME:CEST
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
DTSTART:19810329T030000
RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=3;BYDAY=-1SU
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:CET
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
DTSTART:19961027T030000
RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=10;BYDAY=-1SU
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
UID:DSC-15861
DTSTART;TZID=Europe/Berlin:20190405T160000
SEQUENCE:1554422910
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20190405T170000
URL:https://dresden-science-calendar.de/calendar/en/detail/15861
LOCATION:TUD CRTD\, Fetscherstraße 10501307 Dresden
SUMMARY:Albert: Gene regulatory mechanisms of neocortex development and evo
 lution & CLEANSIGHT: from basic human RPE cell biology to disease modeling
  and therapy discovery
CLASS:PUBLIC
DESCRIPTION:Speaker: Dr. Mareike Albert\nInstitute of Speaker: Dr. Seba Alm
 edawar\nTopics:\nBiologie\, Medizin\n Location:\n  Name: TUD CRTD (CRTD\, 
 auditorium left)\n  Street: Fetscherstraße 105\n  City: 01307 Dresden\n  
 Phone: +49 (0)351 458 82052\n  Fax: +49 (0)351 458 82059 \nDescription: Sp
 eaker: Dr. Mareike Albert Title: Gene regulatory mechanisms of neocortex d
 evelopment and evolution AbstractEpigenetic mechanisms play a pivotal role
  in orchestrating the behavior of stem cells during development. We are in
 terested in the mechanisms that regulate gene expression in neural stem an
 d progenitor cells\, which have implications for our understanding of neoc
 ortex development and evolution as well as neural stem cell regulation.  S
 peaker: Dr. Seba Almedawar Title: CLEANSIGHT: from basic human RPE cell bi
 ology to disease modeling and therapy discovery AbstractInherited and age 
 acquired retinal degenerative diseases (RD) are the primary cause of visio
 n loss in the industrialized world. The retinal pigment epithelium (RPE) i
 s implicated in many RD\, including age related macular degeneration (AMD)
 \, Best1 disease and retinitis pigmentosa. A decade ago\, studying those d
 iseases in vitro was challenging due to limited access to patient RPE\, wh
 ich hampered the development of therapy. In CLEANSIGHT\, we use human plur
 ipotent stem cells derived RPE to study and model RD and develop therapeut
 ic approaches using small molecules or cell replacement therapy. Our estab
 lished screening platform revealed stimulators of photoreceptor outer segm
 ent phagocytosis\, which is a major disease causing phenotype in RD. Curre
 ntly we are validating our favorite hit in vivo and transferring our findi
 ng to industry for drug development. In parallel\, we have made the first 
 steps to transfer our protocol to more defined and animal origin free medi
 a\, which is required for cell replacement therapy. Additionally\, in coll
 aboration with Prof. Marius Ader and Miltenyi Biotec\, we have identified 
 cell surface markers that can be used to purify RPE cells from remnant ste
 m cells before transplantation\, which is a challenge in the field. By est
 ablishing both small molecules and cell replacement therapy approaches\, t
 he best treatment strategy can be chosen based on the RD stage (early vs l
 ate)\, on a patient-to-patient basis.
DTSTAMP:20260409T072507Z
CREATED:20190403T000959Z
LAST-MODIFIED:20190405T000830Z
END:VEVENT
END:VCALENDAR