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UID:DSC-17891
DTSTART;TZID=Europe/Berlin:20210511T164000
SEQUENCE:1620598253
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20210511T181000
URL:https://dresden-science-calendar.de/calendar/en/detail/17891
LOCATION:TUD\,    
SUMMARY:Physikalisches Kolloquium: The mechanical genome
CLASS:PUBLIC
DESCRIPTION:Speaker: \nInstitute of Speaker: \nTopics:\nWillkommen\n Locati
 on:\n  Name: TUD ()\n  Street:   \n  City:  \n  Phone: \n  Fax: \nDescript
 ion: <p>Veranstaltungseinladung als pdf-Download (https://tu-dresden.de/m
 n/physik/ressourcen/dateien/physikalisches-kolloquium/2021-05-11-Phys_Koll
 oq-Schiessel-SoSe2021.pdf).</p>  <p><strong>Kurzfassung</strong>: DNA mol
 ecules carry genetic information. But are there other layers of informatio
 n besides the genes that code for proteins? And could these layers even be
  on top of genes? In this talk I show that this could actually be true. Ba
 sed on a physical model for the DNA double helix and combining it with a n
 ew Monte Carlo technique\, M utation Monte Carlo\, and graph theory\, it i
 s shown that there is space on DNA molecules for a mechanical information 
 layer. This could influence the folding of DNA molecules in the cell and i
 n turn modulate the accessibility of the genetic material. Furthermore\, u
 sing graph theory again\, it is shown that even a third information layer\
 , which could influence the protein folding process\, can be multiplexed w
 ith the other two layers. After providing theoretical support for this ide
 a\, we finally ask whether there is evidence that mechanical information e
 xists on real DNA molecules and speculate about its biological function.</
 p>  <p><strong>Biographie</strong>: Helmut Schiessel studied physics in F
 reiburg where he did his Ph.D. in theoretical polymer physics in 1997. He 
 then worked as a postdoc at two Universities of California\, in Santa Barb
 ara and in Los Angeles. In 2000 he joined the MPI for Polymer Research in 
 Mainz where he was in charge of a biophysics research project. From 2005 t
 o 2020 Schiessel headed the chair of Theoretical Physics of Life Processes
  at the Lorentz Institute\, Leiden University. Since January he heads the 
 group Theoretical Physics of Living Matter at the Cluster of Excellence Ph
 ysics of Life.</p>
DTSTAMP:20261007T041741Z
CREATED:20210416T220620Z
LAST-MODIFIED:20210509T221053Z
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