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CMCB Life Sciences Seminar: Jan Born, University of Tübingen

Date
Jan 26, 2023
Time
1:00 PM - 2:00 PM
Series
CMCB Life Sciences Seminar
Language
en
Main Topic
Willkommen
Other Topics
Willkommen
Description

Host: Henrik Bringmann (BIOTEC)

Title: “Sleep – a brain state serving memory”

Abstract:
Whereas memories are optimally encoded and retrieved when the brain is awake, the consolidation and formation of long-term memory requires an offline mode of processing as optimally established only during sleep. Based on evidence from behavioral and neurobiological studies in humans and rodents, I will consider the formation of long-term memory during sleep as an “active systems consolidation” process in which  the repeated neuronal replay of memory representations originating from the hippocampus during slow-wave sleep (SWS) leads to a gradual transformation and integration of representations into extrahippocampal, mainly neocortical networks. I will highlight three features of this process: (i) Hippocampal replay that, by capturing episodic memory aspects, drives consolidation of representations residing inside and outside the hippocampus; (ii) brain oscillations hallmarking SWS and rapid-eye movement (REM) sleep, respectively, which provide mechanisms to regulate both information flow across distant brain networks and local synaptic plasticity; and (iii) qualitative transformations of memories during sleep-dependent systems consolidation resulting in abstract schema-like representations.

Links

Last modified: Jan 26, 2023, 7:38:52 AM

Location

Center for Regenerative Therapies DresdenFetscherstraße10501307Dresden
Phone
+49 (0)351 458 82052
Fax
+49 (0)351 458 82059
E-Mail
TUD CRTD
Homepage
https://tu-dresden.de/cmcb/crtd

Organizer

Center for Molecular and Cellular Bioengineering (CMCB)01062Dresden
Phone
+49 351 463-40359
Fax
+49 351 463-40322
E-Mail
TUD CMCB
Homepage
https://tu-dresden.de/cmcb
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