CMCB Life Sciences Seminar: Jan Born, University of Tübingen

Date

Jan 26, 2023

Time

1:00 PM - 2:00 PM

Series

CMCB Life Sciences Seminar

Language

en

Main Topic

Willkommen

Other Topics

Willkommen

Description

Host: Henrik Bringmann (BIOTEC)

Title: “Sleep – a brain state serving memory”

Abstract:
Whereas memories are optimally encoded and retrieved when the brain is awake, the consolidation and formation of long-term memory requires an offline mode of processing as optimally established only during sleep. Based on evidence from behavioral and neurobiological studies in humans and rodents, I will consider the formation of long-term memory during sleep as an “active systems consolidation” process in which  the repeated neuronal replay of memory representations originating from the hippocampus during slow-wave sleep (SWS) leads to a gradual transformation and integration of representations into extrahippocampal, mainly neocortical networks. I will highlight three features of this process: (i) Hippocampal replay that, by capturing episodic memory aspects, drives consolidation of representations residing inside and outside the hippocampus; (ii) brain oscillations hallmarking SWS and rapid-eye movement (REM) sleep, respectively, which provide mechanisms to regulate both information flow across distant brain networks and local synaptic plasticity; and (iii) qualitative transformations of memories during sleep-dependent systems consolidation resulting in abstract schema-like representations.

Links

• Termindetails auf den Webseiten der TU Dresden (https://tu-dresden.de)

Last modified: Jan 26, 2023, 7:38:52 AM